Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/8075
Title: In contrast to HIV, KIR3DS1 does not influence outcome in HTLV-1 retroviral infection.
Authors: O’Connor, Geraldine M
Al Basatena, Nafisa-Katrin Seich
Gallazzi, Viviana Nilla Olavarria
MacNamara, Aidan
Vine, Alison
Ying, Qi
Hisada, Michie
Castro Filho, Bernardo Galvão
Asquith, Becca
McVicar, Daniel W
Affilliation: Cancer and Inflammation Program. Laboratory of Experimental Immunology, NCI-Frederick. Frederick, MD, USA
Imperial College London. Department of Immunology. London, United Kingdom
Escola Bahiana de Medicina e Saúde Pública. Centro HTLV. Salvador, BA, Brasil
Imperial College London. Department of Immunology. London, United Kingdom
Imperial College London. Department of Immunology. London, United Kingdom
Cancer and Inflammation Program. Laboratory of Experimental Immunology, SAIC Frederick, NCI-Frederick. Frederick, MD, USA
Takeda Global Research & Development Center. Deerfield, IL, USA
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado em Saúde Pública. Salvador, BA, Brasil
Imperial College London. Department of Immunology. London, United Kingdom
Cancer and Inflammation Program. Laboratory of Experimental Immunology, NCI-Frederick. Frederick, MD, USA
Abstract: While most carriers of human T-cell leukemia virus type 1 (HTLV-1) remain asymptomatic throughout their lifetime, infection is associated with the development of adult T-cell leukemia (ATL) and HTLV-1- associated myelopathy/tropical spastic paraparesis (HAM/TSP). The exact parameters that determine these outcomes are unknown but are believed to include host genetic factors that control the immune response to infection. Host response to fellow retroviridae member HIV is influenced by the expression of members of the Killer Immunoglobulin Receptor (KIR) family including KIR3DS1. In this study we examined the association of KIR3DS1 with the outcome of HTLV-1 infection in three geographically distinct cohorts (Jamaican, Japanese and Brazilian). Despite increased prevalence of KIR3DS1 in the HAM/ TSP patients of the Jamaican cohort, we found no evidence for a role of KIR3DS1 in influencing control of proviral load or disease outcome. This suggests that unlike HIV, KIR3DS1-mediated regulation of HTLV-1 infection does not occur, or is ineffective
DeCS: Grupos Étnicos
Vírus 1 Linfotrópico T Humano/imunologia
Leucemia-Linfoma de Células T do Adulto/imunologia
Paraparesia Espástica Tropical/imunologia
Receptores KIR3DS1/imunologia
Doenças da Medula Espinal/imunologia
Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Doenças Assintomáticas
Criança
Estudos de Coortes
Feminino
Humanos
Jamaica/epidemiologia
Japão/epidemiologia
Leucemia-Linfoma de Células T do Adulto/complicações
Masculino
Meia-Idade
Paraparesia Espástica Tropical/complicações
Prevalência
Receptores KIR3DS1/genética
Doenças da Medula Espinal/complicações
Carga viral
Issue Date: 2012
Publisher: Elsevier Inc
Citation: O' CONNOR, G. M. et al. In contrast to HIV, KIR3DS1 does not influence outcome in HTLV-1 retroviral infection. Human Immunology, v. 73, n. 8, p. 783-787, 2012.
DOI: 10.1016/j.humimm.2012.05.006
ISSN: 1879-1166
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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