Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/8080
Title: Splenectomy increases mortality in murine Trypanosoma cruzi infection
Authors: Maioli, Tatiani Uceli
Assis, Frankcinéia Aparecida de
Vieira, Paula Melo de Abreu
Borelli, Primavera
Santiago, Helton da Costa
Alves, R.
Romanha, Álvaro José
Carneiro, Cláudia Martins
Faria, Ana Maria Caetano de
Affilliation: Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil
Universidade Federal de Ouro Preto. Escola de Farmácia. Departamento de Análises Clínicas. Ouro Preto, MG, Brazil
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas. São Paulo, SP, Brazil
Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas. São Paulo, SP, Brazil
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil
Universidade Federal de Ouro Preto. Escola de Farmácia. Departamento de Análises Clínicas. Ouro Preto, MG, Brazil
Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil
Abstract: The spleen is a secondary lymphoid organ that harbours a variety of cells such as T and B lymphocytes and antigen-presenting cells important to immune response development. In this study, we evaluated the impact of spleen removal in the immune response to experimental Trypanosoma cruzi infection. C57BL/6 mice were infected with Y strain of the parasite and infection was followed daily. Mice that underwent splenectomy had fewer parasites in peripheral blood at the peak of infection; however, mortality was increased. Histological analysis of heart and liver tissues revealed an increased number of parasites and inflammatory infiltrates at these sites. Spleen removal was associated with reduction in IFN-γ and TNF-α production during infection as well as with a decrease in specific antibody secretion. Haematological disorders were also detected. Splenectomized mice exhibited severe anaemia and decreased bone marrow cell numbers. Our results indicate that spleen integrity is critical in T. cruzi infection for the immune response against the parasite, as well as for the control of bone marrow haematological function.
Keywords: Trypanosoma cruzi
Chagas Disease/immunology
Mice
Inbred C57BL
Spleen/immunology
Issue Date: 2011
Publisher: Blackwell Scientific Publications
Citation: MAIOLI, Tatiani Uceli et al. Splenectomy increases mortality in murine Trypanosoma cruzi infection. Scand J Immunol, 73(1): 36-45. 2011
ISSN: 0300-9475
10.1111/j.1365-3083.2010.02478.x
Copyright: open access
Appears in Collections:MG - IRR - Artigos de Periódicos

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