Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/8085
Title: Study of autoantibodies in patients with keratoconjunctivitis sicca infected by the human T cell lymphotropic virus type 1.
Authors: Chaoui, Ana Karina Ferraz
Atta, Ajax Mercês
Atta, Maria Luiza Brito de Sousa
Castro Filho, Bernardo Galvão
Santiago, Mittermayer Barreto
Affilliation: Instituto Brasileiro de Oftalmologia e Prevenção à Cegueira. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, Ba, Brasil
Universidade Federal da Bahia. Immunology Research Laboratory. Clinical and Toxicological Analysis. Faculty of Pharmacy. Salvador, BA, Brasil
Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Serviço de Reumatologia do HSI. Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil
Abstract: Human T cell lymphotropic virus type 1 (HTLV-1) is endemic in many regions of the world, including Brazil, and has been associated to several immunological manifestations such as arthritis, uveitis, dermatitis and Sjögren’s syndrome. This study was intended to evaluate the frequency of autoantibodies in patients infected with HTLV-1 and manifesting keratoconjunctivitis sicca (KCS). HTLV-1 patients with KCS, enrolled in a reference ambulatory of the city of Salvador, were tested for autoantibodies such as antinuclear antibodies, rheumatoid factor, anti- SSA/Ro and anti-SSB/La. Two comparison groups were also included: (a) HTLV-1 patients without KCS and (b) seronegative patients with KCS. Correlation of proviral load (PVL) in HTLV-1 patients with presence or absence of KCS was also assessed. No autoantibodies were detected in HTLV-1 patients with KCS. The PVL of HTLV-1 patients was higher in patients with KCS without other clinical manifestations customarily associated to HTLV-1. In conclusion, in this study, no changes were observed in humoral immunity concerning production of certain autoantibodies in HTLV-1-infected patients with KCS, which suggests that other mechanisms may be involved in the pathogenesis of this manifestation. Additionally, PVL may be a marker of KCS development in these patients.
Keywords: HTLV-1
Autoantibodies
Keratoconjunctivitis sicca
Proviral load
DeCS: Autoanticorpos/sangue
Infecções por HTLV-I/complicações
Ceratoconjuntivite Seca/imunologia
Adulto
Idoso
Anticorpos Antinucleares/análise
Anticorpos Antinucleares/sangue
Autoanticorpos/análise
Marcadores Biológicos/análise
Brasil
Estudo de Coortes
Feminino
Humanos
Imunidade Humoral/fisiologia
Ceratoconjuntivite Seca/sangue
Masculino
Meia-Idade
Provirus/imunologia
Fator Reumatoide/análise
Ribonucleoproteínas/imunologia
Carga Viral
Issue Date: 2010
Publisher: Springer
Citation: FERRAZ-CHAOUI, A. K. et al. Study of autoantibodies in patients with keratoconjunctivitis sicca infected by the human T cell lymphotropic virus type 1. Rheumatology International, v. 30, n. 6, p. 775-778, 2010.
DOI: 10.1007/s00296-009-1066-5
ISSN: 1437-160X
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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