| Author | Kay, Alan | |
| Author | Silva, Edinete Melo da | |
| Author | Pedreira, Henrique | |
| Author | Negreiros, S | |
| Author | Lobato, Cirley | |
| Author | Braga, W | |
| Author | Muwonge, R | |
| Author | Deny, P | |
| Author | Reis, Mitermayer Galvão dos | |
| Author | Zoulim, F | |
| Author | Trépo, Christian | |
| Author | D' Oliveira Junior, Argemiro | |
| Author | Salcedo, Juan Miguel | |
| Author | Schinoni, Maria Isabel | |
| Author | Paraná, Raymundo | |
| Access date | 2014-07-29T17:24:04Z | |
| Available date | 2014-07-29T17:24:04Z | |
| Document date | 2014 | |
| Citation | KAY, A. et al. HBV/HDV co-infection in the Western Brazilian Amazonia: an intriguing mutation among HDV genotype 3 carriers. Journal of Viral Hepatitis, p. 1-5, 2014. | pt_BR |
| ISSN | 1352-0504 | |
| URI | https://www.arca.fiocruz.br/handle/icict/8094 | |
| Language | eng | pt_BR |
| Publisher | Blackwell Scientific Publication | pt_BR |
| Rights | open access | pt_BR |
| Title | HBV/HDV co-infection in the Western Brazilian Amazonia: an intriguing mutation among HDV genotype 3 carriers | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1111/jvh.12267 | |
| Abstract | SUMMARY. HDV infection still remains a serious public
health problem in Amazonia. There are few data regarding
the biomolecular aspects of HBV/HDV co-infection in this
region. We studied 92 patients HBsAg+/anti-HDV IgG+ followed
at the Hepatitis Referral Centers of Porto Velho
(RO), Rio Branco and Cruzeiro do Sul (AC), Brazil, from
March 2006 to March 2007 for whom the HDV and/or
the HBV genotype could be determined. The HDV genotype
could be determined in 90 patients, while the HBV genotypes
could be positively determined in 74. HBV subgenotype
F2 is the most prevalent (40.2%), followed by the
subgenotypes A1 (15.2%) and D3 (8.7%), while 16.4%
were other subgenotypes or genotypes, 4.3% were
discordant and 15.2% were unamplifiable. Surprisingly,
HDV genotype 3 (HDV-3) was found in all of the HBV/
HDV-infected patients that could be genotyped for HDV,
confirming that HDV-3 can associate with non-F HBV
genotypes. However, a HDV-3 mutant was found in 29.3%
of patients and was more frequently associated with non-F
HBV genotypes (P < 0.001) than were nonmutant strains,
suggesting that the mutation may facilitate association of
HDV-3 with non-F HBV genotypes. | pt_BR |
| Affilliation | Inserm. Lyon, France | pt_BR |
| Affilliation | Inserm. Lyon, France | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil | pt_BR |
| Affilliation | Acre State Secretariat of Health. Rio Branco, Brasil | pt_BR |
| Affilliation | Acre State Secretariat of Health. Rio Branco, Brasil | pt_BR |
| Affilliation | Institute of Tropical Medicine of Amazonas. Manaus, AM, Brasil | pt_BR |
| Affilliation | International Agency for Research on Cancer. IARC. World Health Organization. WHO. Lyon, France | pt_BR |
| Affilliation | Inserm. Lyon, France | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil | pt_BR |
| Affilliation | Inserm. Lyon, France / Service d’H epato-Gastroent erology. H^opital de la Croix-Rousse. Lyon, France | pt_BR |
| Affilliation | Inserm. Lyon, France / Service d’H epato-Gastroent erology. H^opital de la Croix-Rousse. Lyon, France | pt_BR |
| Affilliation | University Hospital. Federal University of Bahia. Amazon Hepatitis Group. Salvador, BA, Brasil | pt_BR |
| Affilliation | Federal University of Rondônia. Rondônia, Porto Velho, Brasil / Fundação Oswaldo Cruz. Rondônia, Porto Velho, Brasil | pt_BR |
| Affilliation | University Hospital. Federal University of Bahia. Amazon Hepatitis Group. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / University Hospital. Federal University of Bahia. Amazon Hepatitis Group. Salvador, BA, Brasil | pt_BR |
| Subject | HBV/HDV co-infection | pt_BR |
| Subject | HBV/HDV genotypes | pt_BR |
| Subject | HDV genotype 3 | pt_BR |
| Subject | Mutant HDV genotype 3 | pt_BR |
