Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/8094
Title: HBV/HDV co-infection in the Western Brazilian Amazonia: an intriguing mutation among HDV genotype 3 carriers
Authors: Kay, Alan
Silva, Edinete Melo da
Pedreira, Henrique
Negreiros, S
Lobato, Cirley
Braga, W
Muwonge, R
Deny, P
Reis, Mitermayer Galvão dos
Zoulim, F
Trépo, Christian
D' Oliveira Junior, Argemiro
Salcedo, Juan Miguel
Schinoni, Maria Isabel
Paraná, Raymundo
Affilliation: Inserm. Lyon, France
Inserm. Lyon, France
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
Acre State Secretariat of Health. Rio Branco, Brasil
Acre State Secretariat of Health. Rio Branco, Brasil
Institute of Tropical Medicine of Amazonas. Manaus, AM, Brasil
International Agency for Research on Cancer. IARC. World Health Organization. WHO. Lyon, France
Inserm. Lyon, France
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
Inserm. Lyon, France / Service d’H epato-Gastroent erology. H^opital de la Croix-Rousse. Lyon, France
Inserm. Lyon, France / Service d’H epato-Gastroent erology. H^opital de la Croix-Rousse. Lyon, France
University Hospital. Federal University of Bahia. Amazon Hepatitis Group. Salvador, BA, Brasil
Federal University of Rondônia. Rondônia, Porto Velho, Brasil / Fundação Oswaldo Cruz. Rondônia, Porto Velho, Brasil
University Hospital. Federal University of Bahia. Amazon Hepatitis Group. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / University Hospital. Federal University of Bahia. Amazon Hepatitis Group. Salvador, BA, Brasil
Abstract: SUMMARY. HDV infection still remains a serious public health problem in Amazonia. There are few data regarding the biomolecular aspects of HBV/HDV co-infection in this region. We studied 92 patients HBsAg+/anti-HDV IgG+ followed at the Hepatitis Referral Centers of Porto Velho (RO), Rio Branco and Cruzeiro do Sul (AC), Brazil, from March 2006 to March 2007 for whom the HDV and/or the HBV genotype could be determined. The HDV genotype could be determined in 90 patients, while the HBV genotypes could be positively determined in 74. HBV subgenotype F2 is the most prevalent (40.2%), followed by the subgenotypes A1 (15.2%) and D3 (8.7%), while 16.4% were other subgenotypes or genotypes, 4.3% were discordant and 15.2% were unamplifiable. Surprisingly, HDV genotype 3 (HDV-3) was found in all of the HBV/ HDV-infected patients that could be genotyped for HDV, confirming that HDV-3 can associate with non-F HBV genotypes. However, a HDV-3 mutant was found in 29.3% of patients and was more frequently associated with non-F HBV genotypes (P < 0.001) than were nonmutant strains, suggesting that the mutation may facilitate association of HDV-3 with non-F HBV genotypes.
Keywords: HBV/HDV co-infection
HBV/HDV genotypes
HDV genotype 3
Mutant HDV genotype 3
Issue Date: 2014
Publisher: Blackwell Scientific Publication
Citation: KAY, A. et al. HBV/HDV co-infection in the Western Brazilian Amazonia: an intriguing mutation among HDV genotype 3 carriers. Journal of Viral Hepatitis, p. 1-5, 2014.
DOI: 10.1111/jvh.12267
ISSN: 1352-0504
Copyright: open access
Appears in Collections:RO - Artigos de Periódicos
BA - IGM - Artigos de Periódicos

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