Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/8123
Title: Distribution of human T cell lymphotropic virus type 1 (HTLV-1) subtypes in Brazil: genetic characterization of LTR and tax region.
Authors: Kashima, Simone G
Alcantara, Luiz Carlos Júnior
Takayanagui, Osvaldo Massaiti
Cunha, Marco Aurelio Valtas
Castro Filho, Bernardo Galvão
Oliveira, Maria Socorro Pombo de
Zago, Marco Antonio
Covas, Dimas Tadeu
Affilliation: Molecular Biology Laboratory. Regional Blood Center of Ribeirão Preto. Ribeirão Preto SP, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil
Universidade de São Paulo. Departamento de Neurologia. Ribeirão Preto, SP, Brasil
Bioinformatic Laboratory. Regional Blood Center of Ribeirão Preto. Ribeirão Preto, SP, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil
Instituto Nacional do Cancer. Rio de Janeiro, RJ, Brasil
Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Ribeirão Preto, SP, Brasil
Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Ribeirão Preto, SP, Brasil
Abstract: We report the molecular and epidemiological characterization of 128 human T cell lymphotropic virus type 1 (HTLV-1) isolates from Brazilian patients with different clinical manifestations of the infection. Thirty-two percent of the patients were asymptomatic, 44% had HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), and 23% had adult T cell leukemia/lymphoma (ATLL). Phylogenetic analysis performed using part of the LTR region of the viral genome revealed that all Brazilian isolates belonged to the Cosmopolitan subtype, with the following distribution within the Transcontinental subgroup: 81.6% within the Latin American cluster and 15.8% outside the Latin American cluster. Two isolates belonged to the Japanese subgroup. Molecular analysis of the tax region showed a high nucleotide similarity ( 99%) with 41 prototype sequences, including the ATK-1 isolate. The mean number of nucleotide substitutions ranged from 1 to 8. Five specific nucleotide substitutions, C7401T, T7914C, C7920T, C7982T, and G8231A, were highly conserved among the Brazilian isolates (79.6%), with a frequency ranging from 81.6% to 100% in the sample group and from 18.4% to 24.1% in the prototypes used, suggesting the existence of a molecular signature. These changes were not correlated with a specific clinical status of the patients and could be a molecular characteristic of the HTLV-1 strains that circulate in Brazil.
DeCS: Genes pX/genética
Vírus 1 Linfotrópico T Humano/genética
Sequências Repetidas Terminais/genética
Adolescente
Adulto
Idoso
Brasil/epidemiologia
Feminino
Infecções por HTLV-I/epidemiologia
Humanos
Masculino
Meia-Idade
Epidemiologia Molecular
Dados de Sequência Molecular
Issue Date: 2006
Publisher: Mary Ann Liebert, Inc
Citation: KASHIMA, S. et al. Distribution of human T cell lymphotropic virus type 1 (HTLV-1) subtypes in Brazil: genetic characterization of LTR and tax region. AIDS Reserach Human and Retroviruses, v. 22, n. 10, p. 953-599, 2006.
ISSN: 0889-2229
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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