Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/8125
Title: Peripheral blood mononuclear cells from individuals infected with human T-cell lymphotropic virus type 1 have a reduced capacity to respond to recall antigens
Authors: Mascarenhas, Rita Elizabeth Moreira
Brodskyn, Claudia Ida
Barbosa, Geisa
Clarêncio, Jorge
Andrade Filho, Antonio de Souza
Figueiroa, Frederico
Castro Filho, Bernardo Galvão
Grassi, Maria Fernanda Rios
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado em Saúde Pública. Salvador, BA, Brasil / Bahiana School of Medicine and Public Health. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunoregulação. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado em Saúde Pública. Salvador, BA, Brasil / Bahiana School of Medicine and Public Health. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunoregulação. Salvador, BA, Brasil
Neurology and Neurosurgery Foundation. Salvador, BA, Brasil / Bahiana School of Medicine and Public Health. Salvador, BA, Brasil
Neurology and Neurosurgery Foundation. Salvador, BA, Brasil / Bahiana School of Medicine and Public Health. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado em Saúde Pública. Salvador, BA, Brasil / Bahiana School of Medicine and Public Health. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado em Saúde Pública. Salvador, BA, Brasil / Bahiana School of Medicine and Public Health. Salvador, BA, Brasil
Abstract: Evidence indicates that human T-cell lymphotropic virus type 1 (HTLV-1) infection leads to chronic immunosuppression and a greater susceptibility to infectious diseases. Spontaneous in vitro proliferation of peripheral blood mononuclear cells (PBMC) is an important immunological feature of HTLV-1-infected individuals. However, the association between spontaneous proliferation and immunosuppression is not clear. In this study, we evaluated the cellular immune responses of PBMC from 58 asymptomatic HTLV-1-infected individuals with PBMC showing or not showing spontaneous proliferation. Individuals with PBMC that spontaneously proliferated had increased proportions of CD4 T cells expressing CD45RO and dramatically reduced responses to recall antigens. In addition, frequencies of positive responses to recall antigens were also decreased in HTLV-infected individuals without spontaneous proliferation of PBMC. There was a polyclonal expansion of multiple T-cell receptor V families of CD4 T lymphocytes in patients with spontaneous proliferation. We observed that HTLV-1 induced an immunosuppression characterized by a decrease in the stimulation index to a recall antigen, even in individuals who did not present spontaneous proliferation. On the other hand, only patients with PBMC presenting spontaneous proliferation showed polyclonal activation and increased proportion of CD4 T cells expressing CD45RO.
DeCS: Antígenos/imunologia
Infecções por HTLV-I/imunologia
Vírus 1 Linfotrópico T Humano/imunologia
Tolerância Imunológica/imunologia
Leucócitos Mononucleares/imunologia
Subpopulações de Linfócitos T/imunologia
Adulto
Antígenos CD45/biossíntese
Linfócitos T CD4-Positivos/citologia
Proliferação de Células
Feminino
Humanos
Memória Imunológica
Leucócitos Mononucleares/citologia
Ativação Linfocitária
Masculino
Proteína Tirosina Fosfatase não Receptora Tipo 1
Receptores de Antígenos de Linfócitos T/análise
Issue Date: 2006
Publisher: American Society for Microbiology
Citation: MASCARENHAS, R. E. et al. Peripheral blood mononuclear cells from individuals infected with human T-cell lymphotropic virus type 1 have a reduced capacity to respond to recall antigens. Clinical and Vaccine Immunology, v. 13, n. 5, p. 547-552, 2006.
DOI: 10.1128/CVI.13.5.547–552.2006
ISSN: 1556-6811
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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