Author | Cangussu, Luiz Otavio Freire | |
Author | Teixeira, Rosângela | |
Author | Campos, Erika Fernandes | |
Author | Rampim, G. F. | |
Author | Mingoti, Sueli Aparecida | |
Author | Martins Filho, Olindo Assis | |
Author | Lima, Maria Gerbase de | |
Access date | 2014-08-04T19:23:32Z | |
Available date | 2014-08-04T19:23:32Z | |
Document date | 2011 | |
Citation | CANGUSSU, Luiz Otavio Freire et al. HLA class II alleles and chronic hepatitis C virus infection. Scand J Immunol, 74(3): 282-287,2011 | pt_BR |
ISSN | 0300-9475 | |
URI | https://www.arca.fiocruz.br/handle/icict/8130 | |
Language | eng | pt_BR |
Publisher | Blackwell Scientific Publications | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Lima | pt_BR |
Title | HLA class II alleles and chronic hepatitis C virus infection | pt_BR |
Type | Article | pt_BR |
DOI | 10.1111/j.1365-3083.2011.02568.x. | |
Abstract | The aim of this study was to investigate association of human leucocyte antigens (HLA)-DRB1 and DQB1 polymorphisms with hepatitis C virus (HCV) infection and with the occurrence of severe liver fibrosis/cirrhosis in chronically infected patients. Ninety-nine white patients, from southeast Brazil, with confirmed HCV chronic infection were included in the study. Severe fibrosis/cirrhosis (METAVIR scores F3-F4) was present in 49 patients. HLA-DRB1 specificities and DRB1*11 and DQB1* alleles were determined by PCR-SSP, and their frequencies were compared between patients and a control group of 103 healthy white Brazilian individuals. The results confirmed previous reports of the association of DRB1*11 and DQB1*03 with protection from chronic HCV infection, but did not confirm their association with protection from severe fibrosis/cirrhosis. Furthermore, the results suggested that the polymorphic sites on HLA molecules responsible for protection from chronic HCV infection are encoded not only by the DRB1*1101 and DQB1*0301, as suggested in the literature, but also by other DRB1*11 and DQB1*03 alleles. Thus, we hypothesized that the common polymorphic residues shared by different DRB1*11 and/or DQB1*03 alleles might be responsible for selection of viral epitopes for presentation to CD4(+) T cells, leading to an efficient immune response against the virus. | pt_BR |
Affilliation | Instituto Alfa de Gastroenterologia. Divisão de Hepatite Viral. Belo Horizonte, MG, Brasil/Universidade Federal de Minas Gerais. Hospital das Clínicas. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Instituto Alfa de Gastroenterologia. Divisão de Hepatite Viral. Belo Horizonte, MG, Brasil/Universidade Federal de Minas Gerais. Hospital das Clínicas. Belo Horizonte, MG, Brasil/Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Medicina Interna. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Universidade Federal de São Paulo. Escola Paulista de Medicina. Departamento de Pediatria. Divisão de Imunogenetica São Paulo, SP, Brazil | pt_BR |
Affilliation | Universidade Federal de São Paulo. Escola Paulista de Medicina. Departamento de Pediatria. Divisão de Imunogenetica São Paulo, SP, Brazil | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Exatas. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Universidade Federal de São Paulo. Escola Paulista de Medicina. Departamento de Pediatria. Divisão de Imunogenetica São Paulo, SP, Brazil | pt_BR |
Subject | CD4-Positive T-Lymphocytes | pt_BR |
Subject | Hepatitis C, Chronic/genetics | pt_BR |
Subject | Hepatitis C, Chronic/pathology | pt_BR |
Subject | HLA-DRB1*11 antigen | pt_BR |