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HTLV-2 HORIZONTAL AND VERTICAL TRANSMISSION IN A FAMILY FROM A BRAZILIAN URBAN AREA: SEROEPIDEMIOLOGICAL, CLINICAL AND MOLECULAR STUDY.
Infecções por HTLV-II/transmissão
Vírus 2 Linfotrópico T Humano/imunologia
Transmissão Vertical de Doença Infecciosa
Adulto
Brasil/epidemiologia
Família
Feminino
Infecções por HTLV-II/epidemiologia
Infecções por HTLV-II/virologia
Vírus 2 Linfotrópico T Humano/classificação
Vírus 2 Linfotrópico T Humano/genética
Humanos
Lactente
Dados de Sequência Molecular
Filogenia
Análise de Sequência de DNA
Estudos Soroepidemiológicos
População Urbana
Author
Affilliation
Abstract
Human T cell lymphotropic virus type 2 (HTLV-2) has been shown to be endemic in Brazilian Indians and
among intravenous drug users in urban areas, but transmission of this infection seems to be infrequent in the
general population living in urban areas in Brazil. Six persons in three generations of a Brazilian family were
evaluated to assess HTLV-2 transmission and its molecular features in the positive cases. The index was detected
during screening (HTLV EIA) of donated blood in Fundação Hemominas, Belo Horizonte, Brazil. Confirmatory
serological test and viral typing were performed by Western blotting and polymerase chain reaction.
The family consisted of husband, wife (index case), three daughters, and the mother of the index case.
The husband and one daughter were found positive, thus pointing to horizontal and vertical transmission.
The husband was a truck driver, who reported casual sex during frequent traveling. The positive daughter
was breast-fed for 3 months, as opposed to the remaining two (seronegative), who breast-fed for 1 month. The
index case’s mother was negative. To identify HTLV-2 subtype(s), phylogenetic analysis of the noncoding long
terminal repeat region and part of the env and tax coding regions was performed. These new isolates from
Belo Horizonte are related to subtype IIa but present a molecular variant with extended tax, previously reported
in subtype IIc. Analyzing both LTR and env regions, the family’s sequences clustered with isolates of
Brazilian intravenous drug users and transfusion transmitted virus.
DeCS
Transmissão de Doença InfecciosaInfecções por HTLV-II/transmissão
Vírus 2 Linfotrópico T Humano/imunologia
Transmissão Vertical de Doença Infecciosa
Adulto
Brasil/epidemiologia
Família
Feminino
Infecções por HTLV-II/epidemiologia
Infecções por HTLV-II/virologia
Vírus 2 Linfotrópico T Humano/classificação
Vírus 2 Linfotrópico T Humano/genética
Humanos
Lactente
Dados de Sequência Molecular
Filogenia
Análise de Sequência de DNA
Estudos Soroepidemiológicos
População Urbana
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