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https://www.arca.fiocruz.br/handle/icict/8148
CYTOKINE PROFILE AND IMMUNOMODULATION IN ASYMPTOMATIC HUMAN T-LYMPHOTROPIC VIRUS TYPE 1-INFECTED BLOOD DONORS.
Citokines in HTLV-1
HTLV-1
Immune response in HTLV-1
Immunomodulation in HTLV-1
Citocinas/biossíntese
Infecções por HTLV-I/imunologia
Vírus 1 Linfotrópico T Humano/imunologia
Adulto
Linfócitos T CD4-Positivos/imunologia
Feminino
Anticorpos Anti-HTLV-I/sangue
Humanos
Interferon gama/biossíntese
Células Matadoras Naturais/imunologia
Masculino
Meia-Idade
Author
Affilliation
Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Departamento de Imunologia. Salvador, BA, Brasil
Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Departamento de Imunologia. Salvador, BA, Brasil
Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Departamento de Imunologia. Salvador, BA, Brasil
Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Departamento de Imunologia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil
National Institute of Allergy and Infectious Diseases. National Institutes of Health. Laboratory of Parasitic Diseases. Bethesda, Maryland, USA
Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Departamento de Imunologia. Salvador, BA, Brasil
Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Departamento de Imunologia. Salvador, BA, Brasil
Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Departamento de Imunologia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil
National Institute of Allergy and Infectious Diseases. National Institutes of Health. Laboratory of Parasitic Diseases. Bethesda, Maryland, USA
Abstract
The modulation of the immune response has been used as therapy for clinical disorders associated with human T-lymphotropic virus type 1 (HTLV-1) infection. In this study, the cytokine profile was evaluated in 26 asymptomatic HTLV-1 blood donors. Additionally, both the cell responsible for producing interferon-gamma (IFN-gamma) and the role of exogenous interleukin (IL)-10 in downregulating IFN-gamma production were studied. Cytokine levels were determined in supernatants of unstimulated lymphocyte cultures by enzyme-linked immunosorbent assay. The levels of IFN-gamma, tumor necrosis factor-alpha, IL-5, and IL-10 were higher in supernatants of the lymphocyte cultures taken from HTLV-1-infected donors than in those taken from healthy subjects. Although depletion of CD8+ T cells and natural killer cells did not affect IFN-gamma production, depletion of CD4+ T cells significantly decreased IFN-gamma production. Furthermore, at a concentration of 2 ng/ml, IL-10 had only a minimum effect on IFN-gamma production, although at high concentrations (100 ng/ml), IL-10 decreased IFN-gamma production by 50% in HTLV-1-infected individuals. These data indicate that both T helper 1 and T helper 2 cytokines are elevated in HTLV-1 infection and that IL-10 in high concentrations modulates IFN-gamma production in these patients.
Keywords
Cellular immunity in HTLV-1Citokines in HTLV-1
HTLV-1
Immune response in HTLV-1
Immunomodulation in HTLV-1
DeCS
Doadores de SangueCitocinas/biossíntese
Infecções por HTLV-I/imunologia
Vírus 1 Linfotrópico T Humano/imunologia
Adulto
Linfócitos T CD4-Positivos/imunologia
Feminino
Anticorpos Anti-HTLV-I/sangue
Humanos
Interferon gama/biossíntese
Células Matadoras Naturais/imunologia
Masculino
Meia-Idade
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