Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/8151
Title: Adult T-cell leukemia/lymphoma in northeastern Brazil: a clinical, histopathologic, and molecular study
Authors: Barbosa, Helenemarie Schaer
Bittencourt, Achilea Candida Lisboa
Araújo, Iguaracyra Barreto de Oliveira
Pereira Filho, Carlos Sampaio
Furlan, Roberto
Pedrosa, Célia
Lessa, Gildete
Harrington Junior, William
Castro Filho, Bernardo Galvão
Affilliation: Universidade Federal da Bahia. Escola de Medicina da Bahia. Departamento de Patologia. Salvador, BA, Brasil.
Universidade Federal da Bahia. Escola de Medicina da Bahia. Departamento de Patologia. Salvador, BA, Brasil.
Universidade Federal da Bahia. Escola de Medicina da Bahia. Departamento de Patologia. Salvador, BA, Brasil.
CICAN Oncology State Center. Salvador, BA, Brasil.
San Raffaele Hospital. Experimental Neuroimmunology Unit DIBIT. Milan, Italy.
University Hospital. Retrovirus Laboratory. Salvador, BA, Brasil.
Oncology Nucleus. Salvador, BA, Brasil.
University of Miami. Department of Hematology and Oncology. Miami, Florida, USA.
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
Abstract: The state of Bahia in the northeastern coast of Brazil is a region in which HTLV-I infection is endemic. This study investigated the characteristics of 28 HTLV-I-associated lymphomas/leukemias in this region. HTLV-I-infection diagnosis was based on serologic study, Southern blot analysis, and polymerase chain reaction (PCR) in neoplastic tissue. The main clinical differences between these lymphomas and adult T-cell leukemia (ATL) cases from other endemic areas were as follows. The mean age was 47 years; 20% of the cases occurred in young adults; and a predominance was found among male subjects (2:1), blacks, and of those of mixed race (96%). Histologically, 20 cases were T-cell pleomorphic leukemia/lymphoma, 5 were Mycosis fungoides-like cutaneous lymphoma, and 3 were CD30+ large-cell anaplastic lymphoma. Immunohistochemistry demonstrated 4 cases of CD8+ lymphoma. Proviral genomic sequences were demonstrated by PCR in 9 lymph node biopsy specimens and in 3 skin biopsy specimens. Southern blot was performed and was positive in 8 cases.
Keywords: HTLV-1-positive lymphoma
Adult T-cell leukemia/lymohoma
Pleomorphic lymphoma
DeCS: Vírus 1 Linfotrópico T Humano/isolamento & purificação
Leucemia-Linfoma de Células T do Adulto/epidemiologia
Adolescente
Adulto
Distribuição por Idade
Idoso
Idoso de 80 Anos ou mais
Southern Blotting
Brasil/epidemiologia
DNA Viral/análise
Ensaio de Imunoadsorção Enzimática
Feminino
Anticorpos Anti-HTLV-I/sangue
Vírus 1 Linfotrópico T Humano/genética
Humanos
Imuno-Histoquímica
Imunofenotipagem
Leucemia-Linfoma de Células T do Adulto/patologia
Linfonodos/patologia
Masculino
Reação em Cadeia da Polimerase
Meia-Idade
Estudos Soroepidemiológicos
Distribuição por Sexo
Pele/patologia
Issue Date: 1999
Publisher: Lippincott Williams & Wilkins
Citation: BARBOSA, Helenemarie Schaer et al. Adult T-cell leukemia/lymphoma in northeastern Brazil: a clinical, histopathologic, and molecular study. Journal of Acquired Immune Deficiency Syndromes, v. 21, n. 1, p. 65-71, 1999.
ISSN: 1525-4135
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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