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Title: Risk factors for human T cell lymphotropic virus type I among injecting drug users in northeast Brazil: possibly greater efficiency of male to female transmission.
Authors: Dourado, Inês
Andrade, Tarcísio
Carpenter, Catherine L
Castro Filho, Bernardo Galvão
Affilliation: Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil
Universidade Federal da Bahia. Centro de Estudos e Terapia do Abuso de Drogas. Salvador, BA, Brasil
USC School of Medicine. Department of Preventive Medicine. Los Angeles, CA, USA
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Abstract: It was observed in the city of Salvador, State of Bahia, the highest seroprevalence of human T cell lymphotropic virus type 1 (HTLV-I) infection in Brazil as demonstrated by national wide blood bank surveys. In this paper, we report results of an investigation of drug use and sexual behavior associated with HTLV-I infection among male and female injecting drug users (IDUs) in Salvador. A cross sectional study was conducted in the Historical District of Salvador from 1994-1996 (Projeto Brasil-Salvador) and 216 asymptomatic IDUs were selected using the snowball contact technique. Blood samples were collected for serological assays. Sera were screened for human immunodeficiency virus (HIV-1/2) and HTLV-I/II antibodies by ELISA and confirmed by Western blot. The overall prevalence of HTLV-I/II was 35.2% (76/216). The seroprevalence of HTLV-I, HTLV-II and HIV-I was for males 22%, 11.3% and 44.1% and for females 46.2%, 10.3% and 74.4% respectively. HTLV-I was identified in 72.4% of HTLV positive IDUs. Variables which were significantly associated with HTLV-I infection among males included needle sharing practices, duration of injecting drug use, HIV-I seropositivity and syphilis. Among women, duration of injecting drug use and syphilis were strongly associated with HTLV-I infection. Multivariate analysis did not change the direction of these associations. Sexual intercourse might play a more important role in HTLV-I infection among women than in men.
Keywords: Human T cell lymphotropic virus type I/II (HTLV-I/II)
Human immunodeficiency virus type 1(HIV-1)
Injecting drug use
Snowball sampling
DeCS: Infecções por HTLV-I/epidemiologia
Infecções por HTLV-I/transmissão
Abuso de Substâncias por Via Intravenosa/complicações
Estudos Transversais
Fatores de Risco
Comportamento Sexual
Issue Date: 1999
Publisher: Fiocruz
Citation: DOURADO, I. Risk factors for human T cell lymphotropic virus type I among injecting drug users in northeast Brazil: possibly greater efficiency of male to female transmission. Memórias do Instituto Oswaldo Cruz, v. 94, n. 1, p. 13-18, 1999.
ISSN: 0074-0276
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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