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Title: HTLV-I in Northeast Brazil: differences for male and female injecting drug users.
Authors: Dourado, Inês
Andrade, Tarcísio
Castro Filho, Bernardo Galvão
Affilliation: Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Centro de Estudos e Terapia de Drogas. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Abstract: BACKGROUND: To investigate the seroprevalence of HTLV-I infection among male and female injecting drug users (IDUs). METHODS: A cross-sectional study conducted in Salvador, Brazil, from 1994 to 1996 (Projeto Brasil-Salvador). The study population of 216 asymptomatic IDUs was selected using snowball contact technique. Data on demographics, sexual behavior, and drug use practices were obtained and blood samples collected for serologic assays. Sera were screened for HIV-1/2 and HTLV-I and HTLV-II antibodies by enzyme-linked immunosorbent assay (ELISA) and confirmed by Western blot. RESULTS: The overall prevalence of HTLV-I/II was 35.2% (76 of 216). The seroprevalence of HTLV-I, HTLV-II, and HIV-1 was for males 22.0%, 11.3%, and 44.1%, and for females 46.2%, 10.3%, and 74.4%, respectively. Specific seroprevalence of HTLV-I infection demonstrated linear trend with increasing age and increasing duration of drug use. Using univariate analysis, the variables that were significantly associated with HTLV-I infection among males included needle sharing practices, duration of IDU, HIV-1 seropositivity, and positive test result for syphilis. Among women, duration of injecting drug use and positive test result for syphilis were strongly associated with HTLV-I infection. CONCLUSIONS: Retrovirus infection is highly prevalent among IDUs in Salvador, Brazil and HTLV-I is more common that HTLV-II. Duration of drug use is an important correlate of HTLV-I infection.
Keywords: HTLV-I/II
Injecting drug use
Snowball sampling - Bahia - Brazil
DeCS: Infecções por HTLV-I/epidemiologia
Infecções por HTLV-I/transmissão
Abuso de Substâncias por Via Intravenosa/epidemiologia
Estudos Transversais
Uso Comum de Agulhas e Seringas/estatística & dados numéricos
Assunção de Riscos
Distribuição por Sexo
Comportamento Sexual
Issue Date: 1998
Publisher: Lippincott Williams & Wilkins
Citation: DOURADO, I.; ANDRADE, T.; CASTRO FILHO, B. G. HTLV-I in Northeast Brazil: differences for male and female injecting drug users. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, v. 19, n. 4, p. 426-429, 1998.
ISSN: 1077-9450
Copyright: restricted access
Appears in Collections:BA - IGM - Artigos de Periódicos

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