Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/8220
Title: Paraoxonase 1 gene polymorphisms in angiographically assessed coronary artery disease: evidence for gender interaction among Brazilians.
Authors: Rios, Domingos Lázaro Souza
D’Onofrio, Lorenza O
Cerqueira, Caio Cesar Silva
Silva, Ricardo Bonfim
Carvalho, Heitor Ghissoni de
Santos Filho, Ademar
Castro Filho, Bernardo Galvão
Affilliation: Universidade Estadual do Sudoeste da Bahia. Laboratório de Genética Molecular. Jequié, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Universidade Estadual do Sudoeste da Bahia. Laboratório de Genética Molecular. Jequié, BA, Brasil
Universidade Estadual do Sudoeste da Bahia. Laboratório de Genética Molecular. Jequié, BA, Brasil
Hospital Santa Izabel. Salvador, BA, Brasil
Hospital Santa Izabel. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil
Abstract: BACKGROUND: Paraoxonases (PON) are members of an enzyme family involved in preventing low-density lipoprotein oxidation and therefore protecting against atherosclerotic plaque formation. METHODS: We studied the Met55Leu and Gln192Arg PON1 polymorphisms in 712 patients (437 Caucasian- and 275 African-Brazilians) who underwent coronary angiography. RESULTS: Among Caucasian-Brazilians, the homozygous 55LeuLeu frequency was higher among patients with significant coronary artery disease (CAD, obstructive lesions >/=50%) than among lesion-free controls (51% vs. 30.3%; p=0.022) in females, but not in males. The Gln192Arg PON1 polymorphism was not associated with CAD, although 192GlnGln homozygotes presented lower high-density lipoprotein (HDL)-cholesterol (p=0.035) and higher triglyceride (p=0.012) levels than 192Arg allele carriers among Caucasian-Brazilian males, but not females. No other lipid-genotype association was detected. Multivariate logistic regression corrected for classic CAD risk factors shows that 55LeuLeu PON1 homozygotes were at increased CAD risk (odds ratio OR=2.852; p=0.003) and that this genotype interacted with gender in its association with CAD risk (OR=0.290; p=0.006) among Caucasian-Brazilians. CONCLUSIONS: This report shows that the 55LeuLeu PON1 genotype increases CAD risk among female Caucasian-Brazilians, irrespective of other CAD risk factors. In addition, 192GlnGln PON1 homozygotes show higher triglyceride and lower HDL-cholesterol levels in male Caucasian-Brazilians. No associations were detected among African-Brazilians.
Keywords: African-Brazilians
Coronary artery disease
Paraoxonase
Polymorphism
DeCS: Arildialquilfosfatase/genética
Doença da Artéria Coronariana/genética
Polimorfismo Genético
Alelos
Arildialquilfosfatase/metabolismo
Brasil
HDL-Colesterol/metabolismo
Angiografia Coronária
Doença da Artéria Coronariana/enzimologia
Feminino
Predisposição Genética para Doença
Genótipo
Humanos
Masculino
Meia-Idade
Fatores de Risco
Triglicerídeos/metabolismo
Issue Date: 2007
Publisher: Walter de Gruyter
Citation: RIOS, D. L. S. et al. Paraoxonase 1 gene polymorphisms in angiographically assessed coronary artery disease: evidence for gender interaction among Brazilians. Clinical Chemistry and Laboratory Medicine, v. 45, n. 7, p. 874-878, 2007.
ISSN: 1434-6621
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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