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AutorFigueiredo, Camila Alexandrina Viana
AutorBarreto, Maurício Lima
AutorNeves, Neuza Maria Alcântara
AutorRodrigues, Laura Cunha
AutorCooper, Philip John
AutorCruz Filho, Alvaro Augusto Souza da
AutorPontes-de-Carvalho, Lain Carlos
AutorLemaire, Denise Carneiro
AutorCosta, Ryan dos Santos
AutorAmorim, Leila D
AutorVergara, Candelaria
AutorRafaels, Nicholas
AutorGao, Li
AutorFoster, Cassandra
AutorCampbell, Monica
AutorMathias, Rasika A
AutorBarnes, Kathleen C
Data de acesso2014-08-22T19:26:05Z
Data de disponibilização2014-08-22T19:26:05Z
Data do publicação2013
CitaçãoFIFUEIREDO, C. A. et al. Coassociations between IL10 polymorphisms, IL-10 production, helminth infection, and asthma/wheeze in an urban tropical population in Brazil. Journal of Allergy Clinical Immunology, v. 131, n. 6, p. 1683-1690, 2013.pt_BR
ISSN1097-6825
URIhttps://www.arca.fiocruz.br/handle/icict/8222
Idiomaengpt_BR
EditorAmerican Academy of Allergy, Asthma & Immunologypt_BR
Direito Autoralopen accesspt_BR
TítuloCoassociations between IL10 polymorphisms, IL-10 production, helminth infection, and asthma/wheeze in an urban tropical population in Brazil.pt_BR
Tipo do documentoArticlept_BR
Resumo em InglêsBACKGROUND: Helminth infections are associated with protection against allergies. It is postulated that IL-10 production after helminth infection suppresses skin hypersensitivity and increases IgG4 production, protecting against allergies. OBJECTIVE: We aimed to determine whether IL10 polymorphisms are associated with helminth infection and the risk of wheeze and allergy. METHODS: Twelve IL10 single nucleotide polymorphisms were genotyped in 1353 children aged 4 to 11 years living in a poor urban area in Salvador, Brazil. Wheezing status, Ascaris lumbricoides and Trichuris trichiura infection, IL-10 production by peripheral blood leukocytes stimulated with A lumbricoides extract, serum total IgE levels, specific IgE levels, skin prick test responses to common aeroallergens, and IgG4 and IgE anti-A lumbricoides antibody levels were measured in all children. Association tests were performed by using logistic or linear regression when appropriate, including sex, age, helminth infection, and principal components for ancestry informative markers as covariates by using PLINK. RESULTS: Allele G of marker rs3024496 was associated with the decreased production of IL-10 by peripheral blood leukocytes in response to A lumbricoides stimulation. Allele C of marker rs3024498 was negatively associated with helminth infection or its markers. Marker rs3024492 was positively associated with the risk of atopic wheeze, total IgE levels, and skin prick test responses to cockroach. CONCLUSIONS: Our findings suggest that IL10 polymorphisms might play a role in the production of IL-10, helminth infection, and allergy. We hypothesize that polymorphisms related to protection against helminths, which would offer an evolutionary advantage to subjects in the past, might be associated with increased risk of allergic diseases.pt_BR
AfiliaçãoJohns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, EUA / Instituto de Ciências da Saúde. Salvador, BA, Brasilpt_BR
AfiliaçãoInstituto de Sa ude Coletiva. Salvador, BA, Brasilpt_BR
AfiliaçãoInstituto de Ciências da Saúde. Salvador, BA, Brasilpt_BR
AfiliaçãoLondon School of Hygiene and Tropical Medicine. London, USApt_BR
AfiliaçãoUniversidad San Francisco de Quito. Ecuador, Quito / University of London. Centre for Infection St George’s. London, USApt_BR
AfiliaçãoProAR–N ucleo de Excelência em Asma. Salvador, BA, Brasilpt_BR
AfiliaçãoFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasilpt_BR
AfiliaçãoInstituto de Ciências da Saúde. Salvador, BA, Brasil / Universidade do Estado da Bahia. Departamento de Ciências da Vida. Salvador, BA, Brasilpt_BR
AfiliaçãoInstituto de Ciências da Saúde. Salvador, BA, Brasilpt_BR
AfiliaçãoUniversidade Federal da Bahia. Instituto de Matem atica. Salvador, BA, Brasilpt_BR
AfiliaçãoJohns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, EUApt_BR
AfiliaçãoJohns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, EUApt_BR
AfiliaçãoJohns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, EUApt_BR
AfiliaçãoJohns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, EUApt_BR
AfiliaçãoJohns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, EUApt_BR
AfiliaçãoJohns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, EUApt_BR
AfiliaçãoJohns Hopkins University. Division of Allergy and Clinical Immunology. Baltimore, EUApt_BR
Palavras-chave em inglêsIL10pt_BR
Palavras-chave em inglêsPolymorphismspt_BR
Palavras-chave em inglêsHelminth infectionpt_BR
Palavras-chave em inglêsImmune modulationpt_BR
Palavras-chave em inglêsAllergypt_BR
Palavras-chave em inglêsAsthmapt_BR
Palavras-chave em inglêsSocial changes asthma and allergy in Latin Americapt_BR
DeCSAsma/epidemiologiapt_BR
DeCSAsma/etiologiapt_BR
DeCSHelmintíase/complicaçõespt_BR
DeCSInterleucina-10/biossíntesept_BR
DeCSPolimorfismo Genéticopt_BR
DeCSSons Respiratórios/etiologiapt_BR
DeCSAdolescentept_BR
DeCSAlelospt_BR
DeCSBrasil/epidemiologiapt_BR
DeCSCriançapt_BR
DeCSPré-Escolarpt_BR
DeCSFemininopt_BR
DeCSLigação Genéticapt_BR
DeCSGenótipopt_BR
DeCSHumanospt_BR
DeCSLactentept_BR
DeCSDesequilíbrio de Ligaçãopt_BR
DeCSMasculinopt_BR
DeCSPolimorfismo de Nucleotídeo Únicopt_BR
DeCSPopulação Urbanapt_BR


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