Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/8278
Title: Toxocara seropositivity, atopy and wheezing in children living in poor neighbourhoods in urban Latin American.
Authors: Mendonça, Lívia Ribeiro
Veiga, Rafael Valente
Dattoli, Vitor Camilo Cavalcante
Figueiredo, Camila Alexandrina Viana
Fiaccone, Rosemeire Leovigildo
Santos, Jackson
Cruz Filho, Alvaro Augusto Souza da
Rodrigues, Laura Cunha
Cooper, Philip John
Pontes-de-Carvalho, Lain Carlos
Barreto, Maurício Lima
Neves, Neuza Maria Alcântara
Affilliation: Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil
Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil
Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil
Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil
Universidade Federal da Bahia. Instituto de Matemática. Salvador, BA, Brasil
Universidade Federal da Bahia. Instituto de Matemática. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil
Universidade Federal da Bahia. ProAR. Núcleo de Excelência em Asma. Salvador, BA, Brasil
University of London. London School of Hygiene and Tropical Medicine. London, United Kingdom
Liverpool School of Tropical Medicine. Molecular and Biochemical Parasitology. Liverpool, United Kingdom
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil
Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil
Abstract: BACKGROUND: Toxocara canis and T. cati are parasites of dogs and cats, respectively, that infect humans and cause human toxocariasis. Infection may cause asthma-like symptoms but is often asymptomatic and is associated with a marked eosinophilia. Previous epidemiological studies indicate that T. canis infection may be associated with the development of atopy and asthma. OBJECTIVES: To investigate possible associations between Toxocara spp. seropositivity and atopy and childhood wheezing in a population of children living in non-affluent areas of a large Latin American city. METHODS: The study was conducted in the city of Salvador, Brazil. Data on wheezing symptoms were collected by questionnaire, and atopy was measured by the presence of aeroallergen-specific IgE (sIgE). Skin prick test (SPT), total IgE and peripheral eosinophilia were measured. Toxocara seropositivity was determined by the presence of anti-Toxocara IgG antibodies, and intestinal helminth infections were determined by stool microscopy. FINDINGS: Children aged 4 to 11 years were studied, of whom 47% were seropositive for anti-Toxocara IgG; eosinophilia >4% occurred in 74.2% and >10% in 25.4%; 59.6% had elevated levels of total IgE; 36.8% had sIgE≥0.70 kU/L and 30.4% had SPT for at least one aeroallergen; 22.4% had current wheezing symptoms. Anti-Toxocara IgG was positively associated with elevated eosinophils counts, total IgE and the presence of specific IgE to aeroallergens but was inversely associated with skin prick test reactivity. CONCLUSION: The prevalence of Toxocara seropositivity was high in the studied population of children living in conditions of poverty in urban Brazil. Toxocara infection, although associated with total IgE, sIgE and eosinophilia, may prevent the development of skin hypersensitivity to aeroallergens, possibly through increased polyclonal IgE and the induction of a modified Th2 immune reaction
DeCS: Anticorpos Anti-Helmínticos/sangue
Hipersensibilidade Imediata/epidemiologia
Sons Respiratórios/etiologia
Toxocara/patogenicidade
Toxocaríase/complicações
Animais
Brasil/epidemiologia
Gatos
Criança
Pré-Escolar
Gravidez
Eosinofilia/epidemiologia
Feminino
Humanos
Imunoglobulina E/sangue
Imunoglobulina G/sangue
Masculino
Áreas de Pobreza
Prevalência
Questionários
Testes Cutâneos
População Urbana
Issue Date: 2012
Publisher: Public Library of Science
Citation: MENDONÇA, L. R. Toxocara seropositivity, atopy and wheezing in children living in poor neighbourhoods in urban Latin American. PLoS Neglected Tropical Diseases, v. 6, n. 11, p. e1886, 2012.
DOI: 10.1371/journal.pntd.0001886
ISSN: 1935-2735
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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