Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/8281
Title: Evidence for a modulatory effect of IL-10 on both Th1 and Th2 cytokine production: the role of the environment.
Authors: Figueiredo, Camila Alexandrina Viana
Neves, Neuza Maria Alcântara
Amorim, Leila D
Silva, Nivea B
Pontes-de-Carvalho, Lain Carlos
Cooper, Philip John
Rodrigues, Laura Cunha
Barreto, Maurício Lima
Affilliation: Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil
Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil
Universidade Federal da Bahia. Instituto de Matemática. Salvador, BA, Brasil
Universidade Federal da Bahia. Instituto de Matemática. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Universidad San Francisco de Quito. Quito, Ecuador / University of London. Centre for Infection. St George's. London, UK
London School of Hygiene and Tropical Medicine. London, UK
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil
Abstract: Allergic and other immune-mediated diseases are complex disease states determined by interplay between host genetics and environmental factors. Environmental changes such as fewer infections and reduced exposure to microbial products have been suggested to have led to insufficient regulation of Th1 and Th2 immune responses, causing an increased incidence of inflammatory diseases. The objective of the present study was to investigate the effect of poor living environmental conditions on mitogen-induced production of cytokines (Th1 and Th2) by peripheral blood leukocytes in children living in urban Brazil and investigate the role of IL-10 in modifying this effect. Our data showed that the proportion of children producing Th1 and Th2 cytokines was lower among those with poor living conditions and that this finding was stronger in children producing IL-10. These results provide a possible biologic explanation for the temporal trends of increasing risk of inflammatory diseases observed in populations living in affluent countries.
Keywords: IL-10
Th1/Th2
Environment
Sewage system
Street paving
Immune regulation
DeCS: Citocinas/metabolismo
Habitação
Interleucina-10/farmacologia
Células Th1/metabolismo
Brasil/epidemiologia
Células Cultivadas
Criança
Pré-Escolar
Feminino
Regulação da Expressão Gênica/efeitos de drogas
Humanos
Hipersensibilidade/epidemiologia
Fatores de Risco
Masculino
Fatores Socioeconômicos
Issue Date: 2011
Publisher: Elsevier
Citation: FIGUEIREDO, C. A. et al. Evidence for a modulatory effect of IL-10 on both Th1 and Th2 cytokine production: the role of the environment. Clinical Immunology, v. 139, n. 1, p. 57-64, 2011.
ISSN: 1521-7035
10.1016/j.clim.2010.12.019
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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