Title:	Evidence for a modulatory effect of IL-10 on both Th1 and Th2 cytokine production: the role of the environment.
Authors:	Figueiredo, Camila Alexandrina Viana Neves, Neuza Maria Alcântara Amorim, Leila D Silva, Nivea B Pontes-de-Carvalho, Lain Carlos Cooper, Philip John Rodrigues, Laura Cunha Barreto, Maurício Lima
Affilliation:	Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil Universidade Federal da Bahia. Instituto de Matemática. Salvador, BA, Brasil Universidade Federal da Bahia. Instituto de Matemática. Salvador, BA, Brasil Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil Universidad San Francisco de Quito. Quito, Ecuador / University of London. Centre for Infection. St George's. London, UK London School of Hygiene and Tropical Medicine. London, UK Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil
Abstract:	Allergic and other immune-mediated diseases are complex disease states determined by interplay between host genetics and environmental factors. Environmental changes such as fewer infections and reduced exposure to microbial products have been suggested to have led to insufficient regulation of Th1 and Th2 immune responses, causing an increased incidence of inflammatory diseases. The objective of the present study was to investigate the effect of poor living environmental conditions on mitogen-induced production of cytokines (Th1 and Th2) by peripheral blood leukocytes in children living in urban Brazil and investigate the role of IL-10 in modifying this effect. Our data showed that the proportion of children producing Th1 and Th2 cytokines was lower among those with poor living conditions and that this finding was stronger in children producing IL-10. These results provide a possible biologic explanation for the temporal trends of increasing risk of inflammatory diseases observed in populations living in affluent countries.
Keywords:	IL-10 Th1/Th2 Environment Sewage system Street paving Immune regulation
DeCS:	Citocinas/metabolismo Habitação Interleucina-10/farmacologia Células Th1/metabolismo Brasil/epidemiologia Células Cultivadas Criança Pré-Escolar Feminino Regulação da Expressão Gênica/efeitos de drogas Humanos Hipersensibilidade/epidemiologia Fatores de Risco Masculino Fatores Socioeconômicos
Issue Date:	2011
Publisher:	Elsevier
Citation:	FIGUEIREDO, C. A. et al. Evidence for a modulatory effect of IL-10 on both Th1 and Th2 cytokine production: the role of the environment. Clinical Immunology, v. 139, n. 1, p. 57-64, 2011.
ISSN:	1521-7035 10.1016/j.clim.2010.12.019
Copyright:	open access
Appears in Collections:	BA - IGM - Artigos de Periódicos

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