| Author | Lima, Ana Tereza Cerqueira | |
| Author | Neves, Neuza Maria Alcântara | |
| Author | Pontes-de-Carvalho, Lain Carlos | |
| Author | Costa, Ryan dos Santos | |
| Author | Barbosa Filho, José Maria | |
| Author | Piuvezam, Márcia | |
| Author | Russo, Momtchilo | |
| Author | Barboza, Renato | |
| Author | Oliveira, Eduardo de Jesus | |
| Author | Marinho, Alexsandro | |
| Author | Figueiredo, Camila Alexandrina Viana | |
| Access date | 2014-08-29T18:43:05Z | |
| Available date | 2014-08-29T18:43:05Z | |
| Document date | 2010 | |
| Citation | CERQUEIRA-LIMA, A. T. et al. Effects of Cissampelos sympodialis Eichl. and its alkaloid, warifteine, in an experimental model of respiratory allergy to Blomia tropicalis. Current Drug Targets, v. 11, n. 11, p. 1458-1467, 2010. | pt_BR |
| ISSN | 1873-5592 | |
| URI | https://www.arca.fiocruz.br/handle/icict/8296 | |
| Language | eng | pt_BR |
| Publisher | Bentham Science Publishers Ltd. | pt_BR |
| Rights | open access | pt_BR |
| Title | Effects of Cissampelos sympodialis Eichl. and its alkaloid, warifteine, in an experimental model of respiratory allergy to Blomia tropicalis. | pt_BR |
| Type | Article | pt_BR |
| Abstract | Asthma is one of the most prevalent chronic diseases worldwide. Medicinal plants are historically used in its treatment. The plant Cissampelos sympodialis, known in Northeastern Brazil as "Jarrinha" or "Milona", is used to treat some inflammatory conditions, including asthma. The objective of this study was to evaluate the potential of Cissampelos sympodialis EICHL. extract (CsE) and its isolated alkaloids, especially warifteine (Wa) on a Blomia tropicalis extract (BtE)-induced experimental model of allergy. The respiratory allergy was induced in AJ mice by the administration of BtE. Mice were orally treated with the 400 mg/kg of CsE or 8 mg/kg of total alkaloids fraction (TAF) or 4 mg/kg of Wa and the following parameters were analyzed: (a) total cell numbers in bronchoalveolar fluid (BAF); (b) differential cell numbers in BAF; (c) eosinophil peroxidase (EPO) activity in BAF; (d) IgE serum levels by passive cutaneous anaphylaxis; (e) IL-5, IL-13, IL-10, and IFN-γ levels in BAF; (f) histopathological alterations in the lung. The treatment of the animals with CsE, Wa or TAF led to a reduction in the numbers of total cells and eosinophils in BAF. The same reduction was observed in EPO levels in the BAF. The levels of IL-5 and IL-13 were also reduced in animals treated with Cissampelos sympodialis, while IL-10 levels were significantly increased in the BAF of CsE-treated animals. The treatment also decreased the density of inflammatory cells in the lung by histopathological examination demonstrating the potential of this medicinal plant as new agent for asthma treatment | pt_BR |
| Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Paraíba. Laboratório de Tecnologia Farmacêutica. João Pessoa, PB, Brasil | pt_BR |
| Affilliation | Universidade Federal da Paraíba. Laboratório de Tecnologia Farmacêutica. João Pessoa, PB, Brasil | pt_BR |
| Affilliation | Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Imunologia. São Paulo, SP, Brasil | pt_BR |
| Affilliation | Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Imunologia. São Paulo, SP, Brasil | pt_BR |
| Affilliation | Universidade Federal da Paraíba. Laboratório de Tecnologia Farmacêutica. João Pessoa, PB, Brasil | pt_BR |
| Affilliation | Universidade Federal da Paraíba. Laboratório de Tecnologia Farmacêutica. João Pessoa, PB, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil | pt_BR |
| Subject | Asthma | pt_BR |
| Subject | Blomia tropicalis | pt_BR |
| Subject | Cissampelos sympodialis | pt_BR |
| Subject | Natural products | pt_BR |
| Subject | Warifteine | pt_BR |
| Subject | Cytokines | pt_BR |
| DeCS | Alcaloides/farmacologia | pt_BR |
| DeCS | Asma/quimioterapia | pt_BR |
| DeCS | Asma/imunologia | pt_BR |
| DeCS | Cissampelos/química | pt_BR |
| DeCS | Ácaros/imunologia | pt_BR |
| DeCS | Alcaloides/isolamento & purificação | pt_BR |
| DeCS | Animais | pt_BR |
| DeCS | Asma/metabolismo | pt_BR |
| DeCS | Líquido da Lavagem Broncoalveolar/citologia | pt_BR |
| DeCS | Citocinas/imunologia | pt_BR |
| DeCS | Citocinas/metabolismo | pt_BR |
| DeCS | Peroxidase de Eosinófilo/metabolismo | pt_BR |
| DeCS | Feminino | pt_BR |
| DeCS | Imunoglobulina E/imunologia | pt_BR |
| DeCS | Camundongos | pt_BR |
| DeCS | Camundongos Endogâmicos A | pt_BR |
| DeCS | Modelos Teóricos | pt_BR |
| DeCS | Extratos Vegetais/farmacologia | pt_BR |
| DeCS | Folhas de Planta/química | pt_BR |
| DeCS | Ratos | pt_BR |
| DeCS | Ratos wistar | pt_BR |
