Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/8296
Title: Effects of Cissampelos sympodialis Eichl. and its alkaloid, warifteine, in an experimental model of respiratory allergy to Blomia tropicalis.
Authors: Lima, Ana Tereza Cerqueira
Neves, Neuza Maria Alcântara
Pontes-de-Carvalho, Lain Carlos
Costa, Ryan dos Santos
Barbosa Filho, José Maria
Piuvezam, Márcia
Russo, Momtchilo
Barboza, Renato
Oliveira, Eduardo de Jesus
Marinho, Alexsandro
Figueiredo, Camila Alexandrina Viana
Affilliation: Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil
Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil
Universidade Federal da Paraíba. Laboratório de Tecnologia Farmacêutica. João Pessoa, PB, Brasil
Universidade Federal da Paraíba. Laboratório de Tecnologia Farmacêutica. João Pessoa, PB, Brasil
Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Imunologia. São Paulo, SP, Brasil
Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Imunologia. São Paulo, SP, Brasil
Universidade Federal da Paraíba. Laboratório de Tecnologia Farmacêutica. João Pessoa, PB, Brasil
Universidade Federal da Paraíba. Laboratório de Tecnologia Farmacêutica. João Pessoa, PB, Brasil
Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil
Abstract: Asthma is one of the most prevalent chronic diseases worldwide. Medicinal plants are historically used in its treatment. The plant Cissampelos sympodialis, known in Northeastern Brazil as "Jarrinha" or "Milona", is used to treat some inflammatory conditions, including asthma. The objective of this study was to evaluate the potential of Cissampelos sympodialis EICHL. extract (CsE) and its isolated alkaloids, especially warifteine (Wa) on a Blomia tropicalis extract (BtE)-induced experimental model of allergy. The respiratory allergy was induced in AJ mice by the administration of BtE. Mice were orally treated with the 400 mg/kg of CsE or 8 mg/kg of total alkaloids fraction (TAF) or 4 mg/kg of Wa and the following parameters were analyzed: (a) total cell numbers in bronchoalveolar fluid (BAF); (b) differential cell numbers in BAF; (c) eosinophil peroxidase (EPO) activity in BAF; (d) IgE serum levels by passive cutaneous anaphylaxis; (e) IL-5, IL-13, IL-10, and IFN-γ levels in BAF; (f) histopathological alterations in the lung. The treatment of the animals with CsE, Wa or TAF led to a reduction in the numbers of total cells and eosinophils in BAF. The same reduction was observed in EPO levels in the BAF. The levels of IL-5 and IL-13 were also reduced in animals treated with Cissampelos sympodialis, while IL-10 levels were significantly increased in the BAF of CsE-treated animals. The treatment also decreased the density of inflammatory cells in the lung by histopathological examination demonstrating the potential of this medicinal plant as new agent for asthma treatment
Keywords: Asthma
Blomia tropicalis
Cissampelos sympodialis
Natural products
Warifteine
Cytokines
DeCS: Alcaloides/farmacologia
Asma/quimioterapia
Asma/imunologia
Cissampelos/química
Ácaros/imunologia
Alcaloides/isolamento & purificação
Animais
Asma/metabolismo
Líquido da Lavagem Broncoalveolar/citologia
Citocinas/imunologia
Citocinas/metabolismo
Peroxidase de Eosinófilo/metabolismo
Feminino
Imunoglobulina E/imunologia
Camundongos
Camundongos Endogâmicos A
Modelos Teóricos
Extratos Vegetais/farmacologia
Folhas de Planta/química
Ratos
Ratos wistar
Issue Date: 2010
Publisher: Bentham Science Publishers Ltd.
Citation: CERQUEIRA-LIMA, A. T. et al. Effects of Cissampelos sympodialis Eichl. and its alkaloid, warifteine, in an experimental model of respiratory allergy to Blomia tropicalis. Current Drug Targets, v. 11, n. 11, p. 1458-1467, 2010.
ISSN: 1873-5592
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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