Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/8298
Title: The presence of serum anti-Ascaris lumbricoides IgE antibodies and of Trichuris trichiura infection are risk factors for wheezing and/or atopy in preschool-aged Brazilian children.
Authors: Neves, Neuza Maria Alcântara
Badaró, Samuel J
Santos, Mariese Conceição Alves dos
Pontes-de-Carvalho, Lain Carlos
Barreto, Maurício Lima
Affilliation: Universidade Federal da Bahia. Instituto de Ciências da Saúde. 1Departmento de Ciências da Biointeração. Salvador, BA, Brasil
Universidade Federal da Bahia. Instituto de Ciências da Saúde. 1Departmento de Ciências da Biointeração. Salvador, BA, Brasil
Universidade Federal da Bahia. Instituto de Ciências da Saúde. 1Departmento de Ciências da Biointeração. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Interativa. Salvador, BA, Brasil
Universidade de São Paulo. Instituto de Saúde Coletiva. São Paulo, SP, Brasil / Faculdade de Medicina. Faculdade São Lucas. Rondônia, Brasil
Abstract: BACKGROUND: The elucidation of factors that trigger the development of transient wheezing in early childhood may be an important step toward understanding the pathogenesis of asthma and other allergic diseases later in life. Transient wheezing has been mainly attributed to viral infections, although sensitisation to aeroallergens and food allergens may occur at an early age. In developing countries, intestinal helminthic infections have also been associated with allergy or atopy-related disorders. OBJECTIVE: The aim of this study was to explore the association of Trichuris trichiura and Ascaris lumbricoides infections with wheezing and atopy in early childhood. STUDY DESIGN: A cross-sectional study using a Portuguese-language ISAAC phase I questionnaire, adapted for preschool-aged children, nested in a cohort study of childhood diarrhoea, was conducted on 682 children. Two faecal samples per child were examined for the presence of intestinal helminthic infection. IgE antibodies against three allergenic preparations (Dermatophagoides pteronyssinus, Blomia tropicalis and common child food), as well as against A. lumbricoides antigens, were measured in a sub-sample of these children, whose parents allowed the procedure. Atopy was defined by the presence of levels of serum IgE antibodies ≥0.35 kU/L against at least one of the three tested allergenic preparations. RESULTS: Active T. trichiura infection but not A. lumbricoides infection was positively associated with wheezing in the total studied children population [adjusted OR = 2.60; CI = 1.54;4.38] and in the atopic children sub-population [adjusted OR = 3.07; CI = 1.00;9.43]. The association with atopy was also positive and statistically significant only in the brute analysis [OR = 2.13; CI = 1.03;4.40]. Anti-A. lumbricoides IgE antibodies, but not current A. lumbricoides infection, were positively associated with wheezing in atopic children [adjusted OR = 2.01; CI = 1.00;4.50] and in non-atopic children [adjusted OR = 3.07; CI = 1.13;8.35] and it was also associated with atopy [adjusted OR = 7.29; CI = 3.90; 13.4]. On the other hands, reports of wheezing were not significantly associated with atopy. CONCLUSIONS: These data corroborate previous studies showing that wheezing is predominantly associated with infection in early childhood and shows that anti-A. lumbricoides IgE antibodies, but not active Ascaris infections, are associated with wheezing and atopy. Additionally, the data demonstrate that T. trichiura infection may play a role in the pathogenesis of atopic wheezing in early childhood.
DeCS: Anticorpos Anti-Helmínticos/sangue
Ascaríase/diagnóstico
Ascaris lumbricoides/imunologia
Hipersensibilidade Imediata/diagnóstico
Imunoglobulina E/sangue
Sons Respiratórios/imunologia
Tricuríase/imunologia
Trichuris/imunologia
Animais
Ascaríase/epidemiologia
Ascaríase/imunologia
Brasil/epidemiologia
Pré-Escolar
Estudos de Coortes
Feminino
Humanos
Hipersensibilidade Imediata/epidemiologia
Lactente
Recém-nascido
Masculino
Sons Respiratórios/etiologia
Fatores de Risco
Tricuríase/epidemiologia
Issue Date: 2010
Publisher: BioMed Central
Citation: ALCANTARA-NEVES, N. M. et al. The presence of serum anti-Ascaris lumbricoides IgE antibodies and of Trichuris trichiura infection are risk factors for wheezing and/or atopy in preschool-aged Brazilian children. Respiratory Research, v. 11, p. 114, 2010.
ISSN: 1465-993X
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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