Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/8299
Title: Spontaneous cytokine production in children according to biological characteristics and environmental exposures.
Authors: Figueiredo, Camila Alexandrina Viana
Neves, Neuza Maria Alcântara
Veiga, Rafael Valente
Amorim, Leila D
Dattoli, Vitor Camilo Cavalcante
Mendonça, Lívia Ribeiro
Junqueira, Samuel Badaró
Genser, Bernd
Santos, Mariese
Pontes-de-Carvalho, Lain Carlos
Cooper, Philip John
Rodrigues, Laura Cunha
Barreto, Maurício Lima
Affilliation: Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil
Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil
Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil
Universidade Federal da Bahia. Instituto de Matemática. Salvador, BA, Brasil
Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil
Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil
Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil
Universidade Federal da Bahia. Instituto de Matemática. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Universidad San Francisco de Quito. Quito, Ecuador
London School of Hygiene and Tropical Medicine. London, United Kingdom
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil
Abstract: BACKGROUND: Environmental factors are likely to have profound effects on the development of host immune responses, with serious implications for infectious diseases and inflammatory disorders such as asthma. OBJECTIVE: This study was designed to investigate the effects of environmental exposures on the cytokine profile of children. METHODS: The study involved measurement of T helper (Th) 1 (interferon-gamma), 2 [interleukin (IL)-5 and IL-13], and the regulatory cytokine IL-10 in unstimulated peripheral blood leukocytes from 1,376 children 4-11 years of age living in a poor urban area of the tropics. We also assessed the impact of environmental exposures in addition to biological characteristics recorded at the time of blood collection and earlier in childhood (0-3 years before blood collection). RESULTS: The proportion of children producing IL-10 was greater among those without access to drinking water [p < 0.05, chi-square test, odds ratio (OR) = 1.67]. The proportion of children producing IL-5 and IL-10 (OR = 10.76) was significantly greater in households that had never had a sewage system (p < 0.05, trend test). CONCLUSIONS: These data provide evidence for the profound effects of environmental exposures in early life as well as immune homeostasis in later childhood. Decreased hygiene (lack of access to clean drinking water and sanitation) in the first 3 years of life is associated with higher spontaneous IL-10 production up to 8 years later in life.
Keywords: Age
Breast-feeding
Cytokine profile
IL-10
SCAALA
ewage
Sex
Tap water
DeCS: Exposição Ambiental
Poluentes Ambientais/toxicidade
Sistema Imunológico/efeitos de drogas
Interferon gama/sangue
Interleucina-10/sangue
Fatores Etários
Criança
Pré-Escolar
Feminino
Humanos
Masculino
Esgotos/efeitos adversos
Abastecimento de Água
Issue Date: 2009
Publisher: National Institute of Environmental Health Sciences
Citation: FIGUEIREDO, C. A. et al. Spontaneous cytokine production in children according to biological characteristics and environmental exposures. Environmental Health Perspectives, v. 117, n. 5, p. 845-849, 2009.
DOI: 10.1289/ehp.0800366
ISSN: 1552-9924
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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