Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/8401
Title: Short report: requirement of b cells for delayed type hypersensitivity-like pathology after secondary infection with Leishmania major in resistant C57BL/6 mice
Authors: Dekrey, Gregory K
Jones, Jeremy J
Mbow, M. Lamine
Brodskyn, Claudia Ida
Titus, Richard G
Affilliation: University of Northern Colorado. Department of Biological Sciences. Greeley, Colorado
Colorado State University. Department of Pathology. Fort Collins, Colorado
Centocor, Incorporated, Infectious Diseases. Malvern, Pennsylvania
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Colorado State University. Department of Pathology. Fort Collins, Colorado
Abstract: B cell-deficient C57Bl/6 ( MT) mice were resistant to Leishmania major after both primary and secondary parasite challenge. However, unlike in wild-type mice, secondary infection in MT mice was not accompanied by a marked delayed type hypersensitivity-like response, and interferon- (IFN- ) levels were approximately half of those in wild-type mice. These results suggest that B cells are involved in IFN- production and the pathology of secondary infection.
DeCS: Linfócitos B/imunologia
Hipersensibilidade Tardia/patologia
Leishmania major/imunologia
Leishmaniose Cutânea/imunologia
Animais
Feminino
Interferon gama/biossíntese
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Knockout
Issue Date: 2003
Publisher: American Society of Tropical Medicine and Hygiene
Citation: DEKREY, G. K. et al. Short report: requirement of b cells for delayed type hypersensitivity-like pathology after secondary infection with Leishmania major in resistant C57BL/6 mice. American Journal of Tropical Medicine and Hygiene, v. 69, n. 5, p. 481-483, 2003.
ISSN: 0002-9637
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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