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Title: Type 1 and type 2 responses to Leishmania major
Authors: Rogers, Kathleen A
DeKrey, Gregory K
Mbow, M. Lamine
Gillespie, R. Dean
Brodskyn, Claudia Ida
Titus, Richard G
Affilliation: University of Northern Colorado. Department of Biological Sciences. Greeley, Colorado
University of Northern Colorado. Department of Biological Sciences. Greeley, Colorado
Biopharmaceutical Research, Centocor. Malvern, PA, USA
Colorado State University. College of Veterinary Medicine and Biomedical Sciences. Department of Microbiology, Immunology and Pathology. CO, USA
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
University of Northern Colorado. Department of Biological Sciences. Greeley, Colorado
Abstract: Leishmania major is a protozoan parasite that is transmitted to the mammalian host by its sand fly vector when the fly probes in the host's skin for a blood meal and injects the parasite within its saliva. In mice experimentally infected with L. major, outgrowth of CD4 type 1 (Th1) cells leads to resolution of the infection, but outgrowth of type 2 (Th2) cells exacerbates disease. To design an effective vaccine against the parasite (and other pathogens that induce polarized Th1 and Th2 responses), we must determine the mechanism underlying this phenomenon so that we can design the vaccine to elicit the appropriate (i.e., protective) Th cell. Recent work indicates that Th bias is influenced by a number of signals delivered by antigen-presenting cells, including cytokines and co-stimulatory molecules. Moreover, recent work also suggests that sand fly saliva influences the immune response to L. major and Th polarization. Determining the mechanisms that lead to polarized Th responses should expand our knowledge regarding immunity to L. major, and should add to our understanding of immunoregulation in general
Keywords: Leishmaniasis
Th cell
Antigen-presenting cell
Sand fly
DeCS: Leishmania major/imunologia
Leishmaniose Cutânea/imunologia
Células Th1/imunologia
Apresentação do Antígeno
Antígenos CD/imunologia
Suscetibilidade a Doenças
Proteínas de Insetos/imunologia
Insetos Vetores/parasitologia
Leishmaniose Cutânea/transmissão
Ativação Linfocitária
Camundongos Endogâmicos
Vacinas Protozoárias/imunologia
Proteínas e Peptídeos Salivares/imunologia
Células Th1/secreção
Issue Date: 2002
Publisher: Elsevier Science B.V
Citation: ROGERS, K. A. et al. Type 1 and type 2 responses to Leishmania major. FEMS Microbiology Letters, v. 209, n. 1, p. 1-7, 2002.
ISSN: 0378-1097
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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