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NO EVIDENCE OF OSTEOPOROSIS IN YOUNG HTLV-1-INFECTED CARRIERS
Author
Affilliation
Bahiana School of Medicine and Public Health. EBMSP. Integrative and multidisciplinary Centre of HTLV. Salvador, BA, Brasil
Bahiana School of Medicine and Public Health. EBMSP. Integrative and multidisciplinary Centre of HTLV. Salvador, BA, Brasil
Bahiana School of Medicine and Public Health. EBMSP. Integrative and multidisciplinary Centre of HTLV. Salvador, BA, Brasil
State University of Santa Cruz. UESC. Itabuna, Bahia, Brasil
Bahiana School of Medicine and Public Health. EBMSP. Integrative and multidisciplinary Centre of HTLV. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil
Bahiana School of Medicine and Public Health. EBMSP. Integrative and multidisciplinary Centre of HTLV. Salvador, BA, Brasil
Bahiana School of Medicine and Public Health. EBMSP. Integrative and multidisciplinary Centre of HTLV. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil
Bahiana School of Medicine and Public Health. EBMSP. Integrative and multidisciplinary Centre of HTLV. Salvador, BA, Brasil
Bahiana School of Medicine and Public Health. EBMSP. Integrative and multidisciplinary Centre of HTLV. Salvador, BA, Brasil
State University of Santa Cruz. UESC. Itabuna, Bahia, Brasil
Bahiana School of Medicine and Public Health. EBMSP. Integrative and multidisciplinary Centre of HTLV. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil
Bahiana School of Medicine and Public Health. EBMSP. Integrative and multidisciplinary Centre of HTLV. Salvador, BA, Brasil
Bahiana School of Medicine and Public Health. EBMSP. Integrative and multidisciplinary Centre of HTLV. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil
Abstract
Osteoporosis has been reported among Human T-cell Lymphotropic Virus type 1 (HTLV-1) infected
aged patients with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) diagnosis.
However, the association between osteoporosis and HTLV-1 infection remains unclear. This study
aimed to evaluate the presence of bone disorders in young HTLV-1 asymptomatic individuals. A cross
sectional study was carried out at the HTLV Reference Center in Salvador, Brazil. Forty-seven HTLV-1
infected asymptomatic and 108 healthy subjects aged between 20 to 45 years were included. Biochemical
markers of bone metabolism were measured and bone mineral density (BMD) was determined at the
femoral neck and at the lumbar spine (L1 -L4). Significant low BMD (Z-score <-1 ) was found in HTLV-1
infected individuals (1.177 ± 0.103) compared to control subjects (1.225 ± 0.146). In logistics regression
analysis HTLV-1 infected subjects were more likely to have low BMD (OR = 3.48; 95%CI 1.29- 9.43)
adjusted for low education and body mass index (BMI). Osteoporosis (Z-score <-2) was not found
among HTLV-1-infected group. In conclusion, our results found a low BMD in patients infected with
HTLV-1 compared to uninfected controls. However, osteoporosis was not observed. Further studies
should be conducted to evaluate the relationship between HTLV-1-infection and low BMD.
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