Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/8461
Title: Evidence for the involvement of spinal cord-inhibitory and cytokines-modulatory mechanisms in the anti-hyperalgesic effect of hecogenin acetate, a steroidal sapogenin-acetylated, in mice.
Authors: Quintans, Jullyana de Souza Siqueira
Barreto, Rosana Siqueira de Souza
Lucca Júnior, Waldecy de
Villarreal, Cristiane Flora
Kaneto, Carla Martins
Soares, Milena Botelho Pereira
Branco, Alexsandro
Almeida, Jackson Roberto Guedes da Silva
Taranto, Alex Gutterres
Antoniolli, Angelo Roberto
Freitas, Rivelilson Mendes de
Quintans Junior, Lucindo José
Affilliation: Universidade Federal de Sergipe. UFS. Departamento de Fisiologia. São Cristóvão, SE, Brasil
Universidade Federal de Sergipe. UFS. Departamento de Fisiologia. São Cristóvão, Sergipe, Brasil
Universidade Federal de Sergipe. UFS. Departamento de Fisiologia. São Cristóvão, Sergipe, Brasil
Universidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Biotecnologia e Terapia Celular. Hospital São Rafael. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Biotecnologia e Terapia Celular. Hospital São Rafael. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Biotecnologia e Terapia Celular. Hospital São Rafael. Salvador, BA, Brasil
Universidade Estadual de Feira de Santana. Colegiado de Ciências Farmacêuticas. Feira de Santana, BA, Brasil
Universidade Federal do Vale do São Francisco. Colegiado de Ciências Farmacêuticas. Petrolina, PE, Brasil
Universidade Federal de São João Del-Rei. Curso de Farmácia. Divinópolis, MG, Brasil
Universidade Federal de Sergipe. UFS. Departamento de Fisiologia. São Cristóvão, SE, Brasil
Universidade Federal do Piauí. Departamento de Farmácia. Teresina, PI, Brasil
Universidade Federal de Sergipe. UFS. Departamento de Fisiologia. São Cristóvão, SE, Brasil
Abstract: Hecogenin is a steroidal sapogenin largely drawn from the plants of the genus Agave, commonly known as 'sisal', and is one of the important precursors used by the pharmaceutical industry for the synthesis of steroid hormones. Hecogenin acetate (HA) is a steroidal sapogenin-acetylated that produces antinociceptive activity. Thus, we evaluate the antihyperalgesic profile of HA in mice in inflammatory models, as well as its possible involvement with c-fos expression on spinal cord area and cytokines to produces analgesic profile. Acute pretreatment with HA (5, 10, or 20 mg/kg; i.p.) inhibited the development of mechanical hyperalgesia induced by carrageenan, TNF-α, dopamine and PGE2. Additionally, the immunofluorescence data demonstrated that acute pretreatment with HA, at all doses tested, significantly inhibited Fos-like expression in the spinal cord dorsal horn normally observed after carrageenan-inflammation. Moreover, HA did not affect the motor performance of the mice as tested in the Rota rod test. This antinociceptive profile seems to be related, at least in part, to a reduction of pro-inflammatory cytokines, as IL-1ß. The present results suggest that HA attenuates mechanical hyperalgesia by blocking the neural transmission of pain at the spinal cord levels and by cytokines-inhibitory mechanisms.
Keywords: Hecogenin acetate
Steroidal sapogenin
Spinal cord
C-fos
IL-1β
Pain
Issue Date: 2014
Publisher: MDPI
Citation: QUINTANS, J. S. S. et al. Evidence for the involvement of spinal cord-inhibitory and cytokines-modulatory mechanisms in the anti-hyperalgesic effect of hecogenin acetate, a steroidal sapogenin-acetylated, in mice. Molecules, v. 19, n. 6, p. 8303-8316, 2014.
DOI: 10.3390/molecules19068303
ISSN: 1420-3049
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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