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AutorTrevinõ, Ana
AutorAlcantara, Luiz Carlos Júnior
AutorBenito, Rafael
AutorCaballero, Estrella
AutorAguilera, Antonio
AutorRamos, José Manuel
AutorMendoza, Carmen de
AutorRodríguez, Carmen
AutorGarcía, Juan
AutorIglesias, Manuel Rodrguez
AutorLejarazu, Raúl Ortiz de
AutorRoc, Lourdes
AutorParra, Patricia
AutorEiros, José
Autordel Romero, Jorge
AutorSoriano, Vincent
AutorHTLV Spanish Study Group
Fecha de acceso2014-09-29T12:43:14Z
Fecha de disponibilización2014-09-29T12:43:14Z
Fecha de publicación2014
ReferenciaTREVIÑO, A. et al. Molecular epidemiology and clinical features of human T cell lymphotropic virus type 1 infection in Spain. Aids Research and Human Retroviruses, v. 30, n. 9, p. 856-862, 2014pt_BR
ISSN0889-2229
URIhttps://www.arca.fiocruz.br/handle/icict/8463
Idiomaengpt_BR
EditorMary Ann Liebert, Incpt_BR
Derechos de autoropen accesspt_BR
Palabras clave en PortuguésHTLV-Ipt_BR
Palabras clave en PortuguésRelações sexuaispt_BR
Palabras clave en PortuguésMasculinopt_BR
Palabras clave en PortuguésFemininopt_BR
Palabras clave en PortuguésAdultopt_BR
Palabras clave en PortuguésMielopatia associada ao HTLV-Ipt_BR
Palabras clave en PortuguésLeucemiapt_BR
Palabras clave en PortuguésLinfoma de célulaspt_BR
TítuloMolecular epidemiology and clinical features of human T cell lymphotropic virus type 1 infection in Spainpt_BR
Tipo del documentoArticlept_BR
DOI10.1089/aid.2013.0128
Resumen en InglésHuman T cell lymphotropic virus type 1 (HTLV-1) infection in Spain is rare and mainly affects immigrants from endemic regions and native Spaniards with a prior history of sexual intercourse with persons from endemic countries. Herein, we report the main clinical and virological features of cases reported in Spain. All individuals with HTLV-1 infection recorded at the national registry since 1989 were examined. Phylogenetic analysis was performed based on the long terminal repeat (LTR) region. A total of 229 HTLV-1 cases had been reported up to December 2012. The mean age was 41 years old and 61% were female. Their country of origin was Latin America in 59%, Africa in 15%, and Spain in 20%. Transmission had occurred following sexual contact in 41%, parenteral exposure in 12%, and vertically in 9%. HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) was diagnosed in 27 cases and adult T cell leukemia/lymphoma (ATLL) in 17 subjects. HTLV-1 subtype could be obtained for 45 patients; all but one belonged to the Cosmopolitan subtype a. One Nigerian pregnant woman harbored HTLV-1 subtype b. Within the Cosmopolitan subtype a, two individuals (from Bolivia and Peru, respectively) belonged to the Japanese subgroup B, another two (from Senegal and Mauritania) to the North African subgroup D, and 39 to the Transcontinental subgroup A. Of note, one divergent HTLV-1 strain from an Ethiopian branched off from all five known Cosmopolitan subtype 1a subgroups. Divergent HTLV-1 strains have been introduced and currently circulate in Spain. The relatively large proportion of symptomatic cases (19%) suggests that HTLV-1 infection is underdiagnosed in Spain.pt_BR
AfiliaciónHospital Carlos III. Infectious Diseases Department. Madrid, Spainpt_BR
AfiliaciónFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasilpt_BR
AfiliaciónHospital Clínico Universitario Lozano Blesa. Service of Microbiology. Zaragoza, Spainpt_BR
AfiliaciónHospital Vall d’Hebron. Service of Microbiology. Barcelona, Spainpt_BR
AfiliaciónHospital Conxo-CHUS. Service of Microbiology. Santiago, Spainpt_BR
AfiliaciónHospital General de Elche. Infectious Disease Unit. Elche, Spainpt_BR
AfiliaciónHospital Carlos III. Infectious Diseases Department. Madrid, Spainpt_BR
AfiliaciónCentro Sanitario Sandoval. Madrid, Spainpt_BR
AfiliaciónHospital Cristal-Piñor. Service of Microbiology. Orense, Spainpt_BR
AfiliaciónHospital Universitario Puerta del Mar. Service of Microbiology. Cádiz, Spainpt_BR
AfiliaciónHospital Clínico Universitario. Service of Microbiology. Valladolid, Spainpt_BR
AfiliaciónHospital Miguel Servet. Service of Microbiology. Zaragoza, Spainpt_BR
AfiliaciónHospital Carlos III. Infectious Diseases Department. Madrid, Spainpt_BR
AfiliaciónHospital Clínico Universitario. Service of Microbiology. Valladolid, Spainpt_BR
AfiliaciónHospital Carlos III. Infectious Diseases Department. Madrid, Spainpt_BR
AfiliaciónHospital Carlos III. Infectious Diseases Department. Madrid, Spainpt_BR
AfiliaciónHTLV Spanish Study Grouppt_BR
xmlui.metadata.dc.subject.ods05 Igualdade de gênero


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