| Author | Bastos, Claudilson José de Carvalho | |
| Author | Aras Junior, Roque | |
| Author | Mota, Gildo de Oliveira | |
| Author | Reis, Francisco | |
| Author | Dias, Juarez Pereira | |
| Author | Jesus, Robson Silva de | |
| Author | Freire, Miralba Silva | |
| Author | Araújo, Eline Gomes de | |
| Author | Prazeres, Juliana Moura Bastos | |
| Author | Grassi, Maria Fernanda Rios | |
| Access date | 2014-10-06T19:02:57Z | |
| Available date | 2014-10-06T19:02:57Z | |
| Document date | 2010 | |
| Citation | BASTOS, C. J. C. et al. Clinical outcomes of thirteen patients with acute chagas disease acquired through oral transmission from two urban outbreaks in northeastern Brazil. PLoS Neglected Tropical Diseases, v. 4, n. 6, p. 1-6, 2010. | pt_BR |
| ISSN | 1935-2735 | |
| URI | https://www.arca.fiocruz.br/handle/icict/8517 | |
| Language | eng | pt_BR |
| Publisher | Public Library of Science | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Doença de Chagas | pt_BR |
| Subject in Portuguese | Surtos de Doenças | pt_BR |
| Subject in Portuguese | Doença Aguda | pt_BR |
| Subject in Portuguese | Adolescente | pt_BR |
| Subject in Portuguese | Adulto | pt_BR |
| Subject in Portuguese | Epidemiologia | pt_BR |
| Subject in Portuguese | Diagnóstico | pt_BR |
| Subject in Portuguese | Criança | pt_BR |
| Title | Clinical outcomes of thirteen patients with acute chagas disease acquired through oral transmission from two urban outbreaks in northeastern Brazil | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1371/journal.pntd.0000711 | |
| Abstract | BACKGROUND: Outbreaks of orally transmitted Trypanosoma cruzi continue to be reported in Brazil and are associated with a high mortality rate, mainly due to myocarditis. METHODS: This study is a detailed report on the disease progression of acute Chagas disease in 13 patients who were infected during two micro-outbreaks in two northeastern Brazilian towns. Clinical outcomes as well as EKG and ECHO results are described, both before and after benznidazole treatment. RESULTS: Fever and dyspnea were the most frequent symptoms observed. Other clinical findings included myalgia, periorbital edema, headache and systolic murmur. Two patients died of cardiac failure before receiving benznidazole treatment. EKG and ECHO findings frequently showed a disturbance in ventricular repolarization and pericardial effusion. Ventricular dysfunction (ejection fraction <55%) was present in 27.3% of patients. After treatment, EKG readings normalized in 91.7% of patients. Ventricular repolarization abnormalities persisted in 50% of the patients, while sinus bradycardia was observed in 18%. The systolic ejection fraction normalized in two out of three patients with initially depressed ventricular function, while pericardial effusion disappeared. CONCLUSIONS: Myocarditis is frequently found and potentially severe in patients with acute Chagas disease. Benznidazole treatment may improve clinical symptoms, as well as EKG and ECHO findings. | pt_BR |
| Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Hospital Professor Edgard Santos. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Hospital Professor Edgard Santos. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Hospital Professor Edgard Santos. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Epidemiological Surveillance Department of the Bahia Health Secretary. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Hospital Professor Edgard Santos. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Couto Maia Hospital. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Epidemiological Surveillance Department of the Bahia Health Secretary. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Hospital Professor Edgard Santos. Salvador, BA, Brasil. | pt_BR |
| Affilliation | Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil. | pt_BR |
| DeCS | Doença de Chagas/quimioterapia | pt_BR |
| DeCS | Surtos de Doenças | pt_BR |
| DeCS | Doença Aguda | pt_BR |
| DeCS | Adolescente | pt_BR |
| DeCS | Adulto | pt_BR |
| DeCS | Brasil/epidemiologia | pt_BR |
| DeCS | Doença de Chagas /diagnóstico | pt_BR |
| DeCS | Doença de Chagas /epidemiologia | pt_BR |
| DeCS | Criança | pt_BR |
| DeCS | Ecocardiografia Doppler | pt_BR |
| DeCS | Eletrocardiografia | pt_BR |
| DeCS | Feminino | pt_BR |
| DeCS | Humanos | pt_BR |
| DeCS | Masculino | pt_BR |
| DeCS | Nitroimidazóis /uso terapêutico | pt_BR |
| DeCS | Radiografia Torácica | pt_BR |
| DeCS | Resultado do Tratamento | pt_BR |
| DeCS | Tripanossomicidas /uso terapêutico | pt_BR |
| DeCS | Trypanosoma cruzi /isolamento & purificação | pt_BR |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
