Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/8517
Title: Clinical outcomes of thirteen patients with acute chagas disease acquired through oral transmission from two urban outbreaks in northeastern Brazil
Authors: Bastos, Claudilson José de Carvalho
Aras Junior, Roque
Mota, Gildo de Oliveira
Reis, Francisco
Dias, Juarez Pereira
Jesus, Robson Silva de
Freire, Miralba Silva
Araújo, Eline Gomes de
Prazeres, Juliana Moura Bastos
Grassi, Maria Fernanda Rios
Affilliation: Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.
Universidade Federal da Bahia. Hospital Professor Edgard Santos. Salvador, BA, Brasil.
Universidade Federal da Bahia. Hospital Professor Edgard Santos. Salvador, BA, Brasil.
Universidade Federal da Bahia. Hospital Professor Edgard Santos. Salvador, BA, Brasil.
Epidemiological Surveillance Department of the Bahia Health Secretary. Salvador, BA, Brasil.
Universidade Federal da Bahia. Hospital Professor Edgard Santos. Salvador, BA, Brasil.
Couto Maia Hospital. Salvador, BA, Brasil.
Epidemiological Surveillance Department of the Bahia Health Secretary. Salvador, BA, Brasil.
Universidade Federal da Bahia. Hospital Professor Edgard Santos. Salvador, BA, Brasil.
Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil.
Abstract: BACKGROUND: Outbreaks of orally transmitted Trypanosoma cruzi continue to be reported in Brazil and are associated with a high mortality rate, mainly due to myocarditis. METHODS: This study is a detailed report on the disease progression of acute Chagas disease in 13 patients who were infected during two micro-outbreaks in two northeastern Brazilian towns. Clinical outcomes as well as EKG and ECHO results are described, both before and after benznidazole treatment. RESULTS: Fever and dyspnea were the most frequent symptoms observed. Other clinical findings included myalgia, periorbital edema, headache and systolic murmur. Two patients died of cardiac failure before receiving benznidazole treatment. EKG and ECHO findings frequently showed a disturbance in ventricular repolarization and pericardial effusion. Ventricular dysfunction (ejection fraction <55%) was present in 27.3% of patients. After treatment, EKG readings normalized in 91.7% of patients. Ventricular repolarization abnormalities persisted in 50% of the patients, while sinus bradycardia was observed in 18%. The systolic ejection fraction normalized in two out of three patients with initially depressed ventricular function, while pericardial effusion disappeared. CONCLUSIONS: Myocarditis is frequently found and potentially severe in patients with acute Chagas disease. Benznidazole treatment may improve clinical symptoms, as well as EKG and ECHO findings.
keywords: Doença de Chagas
Surtos de Doenças
Doença Aguda
Adolescente
Adulto
Epidemiologia
Diagnóstico
Criança
DeCS: Doença de Chagas/quimioterapia
Surtos de Doenças
Doença Aguda
Adolescente
Adulto
Brasil/epidemiologia
Doença de Chagas /diagnóstico
Doença de Chagas /epidemiologia
Criança
Ecocardiografia Doppler
Eletrocardiografia
Feminino
Humanos
Masculino
Nitroimidazóis /uso terapêutico
Radiografia Torácica
Resultado do Tratamento
Tripanossomicidas /uso terapêutico
Trypanosoma cruzi /isolamento & purificação
Issue Date: 2010
Publisher: Public Library of Science
Citation: BASTOS, C. J. C. et al. Clinical outcomes of thirteen patients with acute chagas disease acquired through oral transmission from two urban outbreaks in northeastern Brazil. PLoS Neglected Tropical Diseases, v. 4, n. 6, p. 1-6, 2010.
DOI: 10.1371/journal.pntd.0000711
ISSN: 1935-2735
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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