| Author | Vilela, Deyla Duarte Carneiro | |
| Author | Chamusca, Flávia Villela | |
| Author | Andrade, Jorge Clarêncio de Souza | |
| Author | Vallve, Maria de Lourdes Farre | |
| Author | Gonzalez, Ana Cristina | |
| Author | Andrade, Zilton de Araújo | |
| Author | Medrado, Alena Ribeiro Alves Peixoto | |
| Author | Reis, Sílvia Regina de Almeida | |
| Access date | 2014-11-18T19:17:02Z | |
| Available date | 2014-11-18T19:17:02Z | |
| Document date | 2012 | |
| Citation | VILELA, D. D. C. et al. Influence of the HPA axis on the inflammatory response in cutaneous wounds with the use of 670-nm laser photobiomodulation. Journal of Photochemistry and Photobiology: Biology, v. 116, p. 114-120, 2012. | pt_BR |
| ISSN | 1873-2682 | |
| URI | https://www.arca.fiocruz.br/handle/icict/8907 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | open access | pt_BR |
| Title | Influence of the HPA axis on the inflammatory response in cutaneous wounds with the use of 670-nm laser photobiomodulation. | pt_BR |
| Type | Article | pt_BR |
| DOI | dx.doi.org/10.1016/j.jphotobiol.2012.05.018 | |
| Abstract | This study evaluated the influence of hypothalamic–pituitary–adrenal (HPA) axis in cutaneous wounds
subjected to laser biomodulation. A total of 48 rats were divided into two groups: Group I (GI) with 24
adrenalectomized animals and Group II (GII) with 24 non-adrenalectomized animals. Each group was
divided into two subgroups: the irradiated subgroup which laser was applied to four points at the edges
of the wound (670 nm laser, 9 mW) and control subgroup. Rats in each subgroup were sacrificed at 24 or
72 h. Adrenal glands were only removed from GI rats. Three days after adrenalectomy, a cutaneous
wound was made. An immunohistochemical analysis was performed using anti-CD45 and anti-CD8 antibodies.
Flow cytometry was used to count T lymphocytes and their subpopulations in blood. Decreases in
the number of CD45-positive inflammatory cells and in the total numbers of CD8- and CD45-positive cells
were observed in histological sections of adrenalectomized animals subjected to laser biomodulation at
24 h. Similar results were observed for distribution of total lymphocytes in blood (p < 0.05). The action of
670 nm laser does not depend exclusively on HPA axis. It is believed that corticosteroid-promoting
enzymes liberated in non-adrenal tissues may influence immune response under the influence of this
type of phototherapy. | pt_BR |
| Affilliation | Escola Bahiana de Medicina e Saúde Pública. Dentistry Course. Salvador, BA, Brasil | pt_BR |
| Affilliation | Escola Bahiana de Medicina e Saúde Pública. Dentistry Course. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, Brasil | pt_BR |
| Affilliation | Escola Bahiana de Medicina e Saúde Pública. Dentistry Course. Salvador, BA, Brasil | pt_BR |
| Affilliation | Escola Bahiana de Medicina e Saúde Pública. Dentistry Course. Salvador, BA, Brasil | pt_BR |
| Subject | Low-intensity laser therapy | pt_BR |
| Subject | CD8 | pt_BR |
| Subject | CD45 | pt_BR |
| Subject | CD4 | pt_BR |
| Subject | T lymphocytes | pt_BR |
| DeCS | Glândulas Suprarrenais/fisiopatologia | pt_BR |
| DeCS | Sistema Hipotálamo-Hipofisário/fisiopatologia | pt_BR |
| DeCS | Terapia a Laser | pt_BR |
| DeCS | Pele/lesões | pt_BR |
| DeCS | Pele/fisiopatologia | pt_BR |
| DeCS | Glândulas Suprarrenais/cirurgia | pt_BR |
| DeCS | Adrenalectomia/efeitos adversos | pt_BR |
| DeCS | Animais | pt_BR |
| DeCS | Linfócitos T CD4-Positivos/citologia | pt_BR |
| DeCS | Linfócitos T CD8-Positivos/citologia | pt_BR |
| DeCS | Inflamação/sangue | pt_BR |
| DeCS | Inflamação/imunologia | pt_BR |
| DeCS | Inflamação/cirurgia | pt_BR |
| DeCS | Masculino | pt_BR |
| DeCS | Ratos | pt_BR |
| DeCS | Ratos Wistar | pt_BR |
| DeCS | Pele/imunologia | pt_BR |
