Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/8916
Title: CD1a-positive Langerhans cells and their relationship with E-cadherin in ameloblastomas and keratocystic odontogenic tumors.
Authors: Mello, Leonardo Araújo
Figueiredo, Andreia Leal
Ramos, Eduardo Antônio Gonçalves
Gurgel, Clarissa Araújo Silva
Martins, Manoela Domingues
Figueiredo, Claudia Roberta Leite Vieira de
Cury, Patrícia Ramos
Albuquerque Junior, Ricardo Luiz Cavalcanti de
Ramalho, Luciana Maria Pedreira
Santos, Jean Nunes dos
Affilliation: Federal University of Bahia
Federal University of Bahia. School of Dentistry. Department of Dental Public Health. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Department of Oral Pathology. Salvador, BA, Brasil
Federal University of Rio Grande do Sul. School of Dentistry. Departament of Oral Pathology. Porto Alegre, RS, Brasil
Federal University of Paraíba. Department of General Pathology. João Pessoa, PB, Brasil
Federal University of Bahia. School of Dentistry. Department of Periodontics. Salvador, BA, Brasil
Laboratory of Morphology and Structural Biology. Aracaju, SE, Brasil
Federal University of Bahia. School of Dentistry. Department of Stomatology. Salvador, BA, Brasil
Federal University of Bahia
Abstract: BACKGROUND: Ameloblastomas and keratocystic odontogenic tumors (KOTs) are lesions that are characterized by locally invasive growth and cause extensive bone destruction. In addition, it is known that E-cadherin influences the adhesion of Langerhans cells (LCs) to keratinocytes. OBJECTIVE AND METHODS: The aim of this study was to investigate, using immunohistochemistry, the distribution of CD1a-positive cells in ameloblastomas and KOTs and their relationship with E-cadherin, in comparison to calcifying cystic odontogenic tumor (CCOT). RESULTS: The CD1a-positive LCs were observed in 11 ameloblastomas and KOTs. All of the cases of CCOT showed CD1a-positive LCs and a significant difference was found when this tumor was compared with ameloblastomas (P < 0.05, Mann-Whitney test). A statistically significant difference was also noted when comparing CD1a-positive LCs between CCOTs and KOTs (P < 0.05, Mann-Whitney test). Lower expression of E-cadherin in ameloblastomas (AMs) in relation to KOTs and CCOTs (P < 0.05, Fisher test) was observed. There was no correlation between E-cadherin and CD1a-positive LCs between all odontogenic tumors that were studied (P > 0.05, Spearman test). CONCLUSION: A quantitative difference of CD1a-positive cells between AMs and KOTs in comparison to CCOTs was observed. This permits to speculate that a depletion of CD1a-positive LCs might influence the local invasiveness of ameloblastomas and KOTs. Furthermore, it is suggested that E-cadherin mediates cell adhesion in these tumors.
Keywords: Dendritic cell
E-cadherin
Langerhans cell
Odontogenic tumors
DeCS: Ameloblastoma/patologia
Antígenos CD1/análise
Caderinas/análise
Células de Langerhans/patologia
Tumores Odontogênicos/patologia
Adolescente
Adulto
Idoso de 80 Anos ou mais
Idoso
Adesão Celular/fisiologia
Contagem de Células
Forma Celular
Criança
Células Dendríticas/patologia
Células Epiteliais/patologia
Feminino
Humanos
Imuno-Histoquímica
Queratinócitos/patologia
Masculino
Neoplasias Mandibulares/patologia
Cisto Odontogênico Calcificante/patologia
Issue Date: 2013
Publisher: John Wiley & Sons Ltd
Citation: MELO, L. A. et al. CD1a-positive Langerhans cells and their relationship with E-cadherin in ameloblastomas and keratocystic odontogenic tumors. Journal of Oral Pathology & Medicine, v. 42, n. 6, p. 454-461, 2013.
DOI: 10.1111/jop.12033
ISSN: 1600-0714
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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