| Author | Conceição, Jamile Gomes | |
| Author | Gurgel, Clarissa Araújo Silva | |
| Author | Ramos, Eduardo Antônio Gonçalves | |
| Author | Xavier, Flávia Caló De Aquino | |
| Author | Salesa, Caroline Brandi Schlaepfer | |
| Author | Cangussú, Maria Cristina Teixeira | |
| Author | Cury, Patrícia Ramos | |
| Author | Ramalho, Luciana Maria Pedreira | |
| Author | Santos, Jean Nunes dos | |
| Access date | 2014-11-21T14:05:53Z | |
| Available date | 2014-11-21T14:05:53Z | |
| Document date | 2013 | |
| Citation | CONCEIÇÃO, J. G. et al. Oral mucoceles: a clinical, histopathological and immunohistochemical study. Acta Histochemica, v. 116, n. 1, p. 40-47, 2014. | pt_BR |
| ISSN | 1618-0372 | |
| URI | https://www.arca.fiocruz.br/handle/icict/8935 | |
| Language | eng | pt_BR |
| Publisher | Elsevier | pt_BR |
| Rights | open access | pt_BR |
| Title | Oral mucoceles: a clinical, histopathological and immunohistochemical study. | pt_BR |
| Type | Article | pt_BR |
| DOI | dx.doi.org/10.1016/j.acthis.2013.04.015 | |
| Abstract | tThe aim of study was to evaluate the clinicopathological features of oral mucoceles and the immunohisto-chemical expression of cellular and extracellular matrix components in these lesions. One hundred casesof oral mucoceles were examined for clinicopathological features. The expression of mast cell tryptase,CD68, MMP-1 (matrix metalloproteinase-1), MMP-9 (matrix metalloproteinase-9) and CD34 was inves-tigated immunohistochemically in 32 cases. The lesions arose as nodules or blisters of variable color. Themean age was 23.2 years and a higher male frequency was observed. The most common locations werethe lower lip (92%), followed by the floor of the mouth (7%), and palate (1%). The lesion size ranged from0.4 to 3.0 cm. Unusual histopathological findings as superficial mucoceles (n = 16, 16%), pseudopapillaryprojections (n = 3, 3%), epithelioid histiocytes (n = 4, 4%), multinucleated giant cells (n = 1, 1%) and myx-oglobulosis (n = 9, 9%) were also seen. Mast cells and CD68-positive macrophages, MMP-1, MMP-9 andCD34-positive blood vessels were seen in all cases. A significant association was seen between mast cellsand MMP-1 (p = 0.03) and between macrophages and MMP-1 (p = 0.01). This study provided importantinsight into the demographic and histopathological occurrence of oral mucoceles. The tissue remodel-ing seen in these lesions mainly involved the migration and interaction of mast cells, macrophages andMMP-1. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil | pt_BR |
| Affilliation | Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
| Affilliation | Federal University of Bahia. School of Dentistry. Department of Dental Public Health. Salvador, BA, Brasil | pt_BR |
| Affilliation | Federal University of Bahia. School of Dentistry. Department of Periodontics. Salvador, BA, Brasil | pt_BR |
| Affilliation | Federal University of Bahia. School of Dentistry. Department of Stomatology. Salvador, BA, Brasil | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Salvador, BA, Brasil | pt_BR |
| Subject | Oral mucoceles | pt_BR |
| Subject | Histopathology | pt_BR |
| Subject | Myxoglobulosis | pt_BR |
| Subject | Immunohistochemistry | pt_BR |
