tThe aim of study was to evaluate the clinicopathological features of oral mucoceles and the immunohisto-chemical expression of cellular and extracellular matrix components in these lesions. One hundred casesof oral mucoceles were examined for clinicopathological features. The expression of mast cell tryptase,CD68, MMP-1 (matrix metalloproteinase-1), MMP-9 (matrix metalloproteinase-9) and CD34 was inves-tigated immunohistochemically in 32 cases. The lesions arose as nodules or blisters of variable color. Themean age was 23.2 years and a higher male frequency was observed. The most common locations werethe lower lip (92%), followed by the floor of the mouth (7%), and palate (1%). The lesion size ranged from0.4 to 3.0 cm. Unusual histopathological findings as superficial mucoceles (n = 16, 16%), pseudopapillaryprojections (n = 3, 3%), epithelioid histiocytes (n = 4, 4%), multinucleated giant cells (n = 1, 1%) and myx-oglobulosis (n = 9, 9%) were also seen. Mast cells and CD68-positive macrophages, MMP-1, MMP-9 andCD34-positive blood vessels were seen in all cases. A significant association was seen between mast cellsand MMP-1 (p = 0.03) and between macrophages and MMP-1 (p = 0.01). This study provided importantinsight into the demographic and histopathological occurrence of oral mucoceles. The tissue remodel-ing seen in these lesions mainly involved the migration and interaction of mast cells, macrophages andMMP-1.