Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/8987
Title: Antinociceptive properties of bergenin
Authors: Oliveira, Cristiane Metzker de
Nonato, Fabiana Regina
Lima, Flávia Oliveira de
Couto, Ricardo David
David, Juceni Pereira de Lima
David, Jorge Mauricio
Soares, Milena Botelho Pereira
Villarreal, Cristiane Flora
Affilliation: Universidade Federal da Bahia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Universidade Estadual de Feira de Santana. Feira de Santana, BA, Brasil
Universidade Federal da Bahia. Salvador, BA, Brasil
Universidade Federal da Bahia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil
Universidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract: Bergenin (1) is a C-glucoside of 4-O-methylgallic acid with known antiarthritic activity attributed to modulation of cytokine production. The present study was undertaken to evaluate whether 1 has antinociceptive properties in models of inflammatory pain and to investigate its possible mechanisms of action. Pretreatment with 1 (12.5-100 mg/kg, ip) produced a dose-related inhibition of acetic acid-induced writhing in mice. Furthermore, treatment with 1 (50 and 100 mg/kg) inhibited both the early and late phases in a formalin test. In addition, 1 (50 and 100 mg/kg, ip) inhibited mechanical hyperalgesia, edema, and paw production of hyperalgesic cytokines (TNF-α and IL-1ß) induced by complete Freund's adjuvant. However, the local production of IL-10, an anti-inflammatory cytokine, was not altered by 1 (100 mg/kg, ip). Treatment with 1 produced a similar profile of antinociception in wild-type and IL-10-deficient mice. Mice treated with 1 did not show any motor performance alterations or apparent systemic toxicity. The results presented herein demonstrate that bergenin has consistent antinociceptive and anti-inflammatory properties, acting by the inhibition of IL-1ß and TNF-α production, and suggest its potential for the control of inflammatory pain.
DeCS: Analgésicos/farmacologia
Anti-Inflamatórios não Esteroides/farmacologia
Benzopiranos/farmacologia
Dor/quimioterapia
Analgésicos/química
Animais
Anti-Inflamatórios não Esteroides/química
Benzopiranos/química
Relação Dose-Resposta a Droga
Edema/induzido quimicamente
Ácido Gálico/análogos & derivados
Interleucina-10/antagonistas & inibidores
Interleucina-10/biossíntese
Masculino
Camundongos
Dor/induzido quimicamente
Medição da Dor
Fator de Necrose Tumoral alfa/antagonistas & inibidores
Issue Date: 2011
Publisher: American Chemical Society
Citation: OLIVEIRA, C. M. et al. Antinociceptive properties of bergenin. Journal of Natural Products, v. 74, n. 10, p. 2062-2068, 2011.
DOI: dx.doi.org/10.1021/np200232s
ISSN: 1520-6025
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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