Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/9002
Title: Approaches for the development of new anti-Trypanosoma cruzi agents
Authors: Moreira, Diogo Rodrigo Magalhães
Leite, Ana Cristina Lima
Santos, Ricardo Ribeiro dos
Soares, Milena Botelho Pereira
Affilliation: Universidade Federal de Pernambuco. Laboratório de Planejamento, Avaliação e Síntese de Fármacos. Departamento de Ciências Farmacêuticas, Recife, PE, Brasil
Universidade Federal de Pernambuco. Laboratório de Planejamento, Avaliação e Síntese de Fármacos. Departamento de Ciências Farmacêuticas, Recife, PE, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Av. São Rafael. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Av. São Rafael. Salvador, BA, Brasil
Abstract: The recent highlights on the biochemical pathways of Trypanosoma cruzi have allowed a significant improvement in the development of new strategies for drug design and also in the understanding of the mechanisms of action of new trypanocidal agents. Several biochemical pathways of fundamental importance and validated targets (e.g. cysteine protease cruzain, trypanothione reductase, trans-sialidase) of T. cruzi have proved usefulness for drug development in many examples of new candidates to anti-T. cruzi drugs. This review will focus on some approaches used for the design of new potential trypanocidal agents, exploring modern concepts of medicinal chemistry such as bioisosterism, molecular hybridization, bioinspired design in lead compounds, as well as the complexation of transition metals with bioactive ligands. The examples discussed in this article may serve as lessons for the antitrypanosomal drug design
Keywords: Chagas' disease
Chemotherapy
Rational drug design
Medicinal chemistry
Trypanosoma cruzi
DeCS: Doença de Chagas/quimioterapia
Tripanossomicidas/farmacologia
Trypanosoma cruzi/efeitos de drogas
Animais
Doença de Chagas/parasitologia
Sistemas de Liberação de Medicamentos
Desenho de Drogas
Humanos
Ligantes
Tripanossomicidas/uso terapêutico
Issue Date: 2009
Publisher: Bentham Science Publishers Ltd
Citation: MOREIRA, D. R. M. et al. Approaches for the development of new anti-Trypanosoma cruzi agents. Current Drug Targets, v. 10, n. 3, p. 212-231, 2009
ISSN: 1873-5592
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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