Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/9142
Title: External genital human papillomavirus prevalence and associated factors among heterosexual men on 5 continents.
Authors: Vardas, Eftyhia
Giuliano, Anna R
Goldstone, Stephen
Palefsky, Joel M
Moreira Júnior, Edson Duarte
Penny, Mary E
Aranda, Carlos
Jessen, Heiko
Moi, Harald
Ferris, Daron G
Liaw, Kai-Li
Marshall, J. Brooke
Vuocolo, Scott
Barr, Eliav
Haupt, Richard M
Garner, Elizabeth I. O
Guris, Dalya
Affilliation: University of Stellenbosch. Division of Medical Virology. Johannesburg, South Africa / Lancet Laboratories. Johannesburg, South Africa
Risk Assessment Detection, and Intervention Program, H. Lee Moffitt Cancer Center. Tampa, Florida / Research Institute. Tampa, Florida
Mount Sinai School of Medicine. New York, New York
University of California. Department of Medicine. San Francisco, San Francisco, California
Associação Obras Sociais Irmã Dulce. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Instituto de Investigación Nutricional. Lima, Peru
University Medical Center. National Public Health Institute. Morelos, Mexico
J2: Private Clinic for Infectious Diseases. Berlin, Germany
University of Oslo. Olafia STI Clinic. Oslo University Hospital. Oslo, Norway
Medical College of Georgia. Gynecologic Cancer Prevention Center. Augusta, Georgia
Merck. North Wales, Pennsylvania
Merck. North Wales, Pennsylvania
Merck. North Wales, Pennsylvania
Merck. North Wales, Pennsylvania
Merck. North Wales, Pennsylvania
Merck. North Wales, Pennsylvania
Merck. North Wales, Pennsylvania
Abstract: BACKGROUND: We examined the baseline prevalence of penile, scrotal, and perineal/perianal human papillomavirus (HPV) in heterosexual men (HM). We also evaluated baseline characteristics of HM to assess factors associated with prevalent HPV detection. METHODS: We tested serum samples from 3463 HM aged 16-24 years with 1-5 lifetime female sexual partners for antibodies to HPV 6, 11, 16, and 18. We collected baseline swab specimens for the detection of DNA of HPV 6, 11, 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, and 59 from 3 areas: penile, scrotal, and perineal/perianal. Risk factors for prevalent HPV DNA detection were evaluated. RESULTS: The prevalence of any tested HPV type was 18.7% at the penis, 13.1% at the scrotum, 7.9% at the perineal/perianal region, and 21.0% at any site. Having >3 lifetime female sexual partners had the greatest impact on HPV prevalence: odds ratio (OR) 3.2 (95% confidence interval (CI) 2.1-4.9) for HPV 6, 11, 16, and 18; and OR 4.5 (95% CI 3.3-6.1) for all HPV types tested. HPV DNA detection was highest in Africa. Neither condom usage nor circumcision was associated with HPV DNA prevalence. CONCLUSION: Genital-HPV DNA detection is common in young, sexually active HM. We found HPV to be most prevalent in African men and least prevalent in men from the Asia-Pacific region. Increased numbers of sexual partners was an important risk factor for HPV DNA prevalence.
DeCS: Doenças dos Genitais Masculinos/epidemiologia
Heterossexualidade
Papillomaviridae/isolamento & purificação
Infecções por Papillomavirus/epidemiologia
Adolescente
Adulto
Canal Anal/virologia
Anticorpos Antivirais/sangue
DNA Viral/genética
DNA Viral/isolamento & purificação
Doenças dos Genitais Masculinos/virologia
Humanos
Masculino
Papillomaviridae/classificação
Infecções por Papillomavirus/virologia
Pênis/virologia
Períneo/virologia
Prevalência
Fatores de Risco
Escroto/virologia
Adulto Jovem
Issue Date: 2011
Publisher: Oxford University Press
Citation: VARDAS, E. et al. External genital human papillomavirus prevalence and associated factors among heterosexual men on 5 continents. Journal of Infectious Diseases, v. 203, n. 1, p. 58-65, 2011.
DOI: 10.1093/infdis/jiq015
ISSN: 1537-6613
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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