Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/9212
Title: Experimental model of chronic osteomyelitis caused by Leishmania (L) amazonensis.
Authors: Costa, Af Ali Uthant Moreira Lima da
Abreu, Ana Lucia
Gomes, Claudia Maria de Castro
Saldanha, Ana Cristina Rodrigues
Barral, Aldina Maria Prado
Costa, Jackson Mauricio Lopes
Corbett, Carlos Eduardo Pereira
Affilliation: Federal University of Maranhão. Nucleus of Tropical Pathology and Social Medicine. São Luís, MA, Brasil / University of São Paulo. Faculty of Medicine. Laboratory of Pathology of Infectious Diseases. Department of Pathology. São Paulo, SP, Brasil
State University of Maranhão. Faculty of Veterinary Medicine. Laboratory of Histology. São Luís, MA, Brasil
University of São Paulo. Faculty of Medicine. Laboratory of Pathology of Infectious Diseases. Department of Pathology. São Paulo, SP, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Federal University of Maranhão. Nucleus of Tropical Pathology and Social Medicine. São Luís, MA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
University of São Paulo. Faculty of Medicine. Laboratory of Pathology of Infectious Diseases. Department of Pathology. São Paulo, SP, Brasil
Abstract: Experimental animal models have been used for the study of the physiopathogenesis of leishmaniasis, on some occasions with success, while in other situations such as bone alterations that accompany tegumentary leishmaniasis, especially in diffuse cutaneous form (DCL), the mechanisms are still unknown. In the present study, we determined these alterations in an animal model susceptible to Leishmania (L) amazonensis. Amastigotes of L. (L) amazonensis isolated from patients with diffuse cutaneous leishmaniasis (DCL) were inoculated into the hind paws of eight BALB/c mice, macroscopic and histopathological aspects were analyzed. After 90 and 120 days of evolution, histopathological analysis demonstrated a mononuclear cell infiltrate rich in plasma cells and intense parasitism of intra- and extra-medullary macrophages, with areas of bone necrosis and discrete involvement of cartilaginous tissue. The results show that the inflammatory process developed during L. (L) amazonensis infection might cause bone tissue destruction and secondarily affect the joints
Keywords: Osteomyelitis
Pathology
Diffuse cutaneous leishmaniasis
Experimental model
DeCS: Leishmania/crescimento & desenvolvimento
Leishmaniose Tegumentar Difusa/patologia
Osteomielite/parasitologia
Animais
Modelos Animais de Doenças
Membro Posterior/parasitologia
Membro Posterior/patologia
Histocitoquímica
Humanos
Leishmaniose Tegumentar Difusa/imunologia
Leishmaniose Tegumentar Difusa/parasitologia
Macrófagos/imunologia
Macrófagos/parasitologia
Macrófagos/patologia
Masculino
Camundongos
Camundongos Endogâmicos BALB C
Osteomielite/imunologia
Osteomielite/patologia
Issue Date: 2006
Publisher: Elsevier
Citation: COSTA, Af Ali U. M. et al. Experimental model of chronic osteomyelitis caused by Leishmania (L) amazonensis. Acta Tropica, v. 98, n. 2, p. 125-129, 2006.
ISSN: 0001-706X
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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