Please use this identifier to cite or link to this item:
https://www.arca.fiocruz.br/handle/icict/9212
EXPERIMENTAL MODEL OF CHRONIC OSTEOMYELITIS CAUSED BY LEISHMANIA (L) AMAZONENSIS.
Leishmaniose Tegumentar Difusa/patologia
Osteomielite/parasitologia
Animais
Modelos Animais de Doenças
Membro Posterior/parasitologia
Membro Posterior/patologia
Histocitoquímica
Humanos
Leishmaniose Tegumentar Difusa/imunologia
Leishmaniose Tegumentar Difusa/parasitologia
Macrófagos/imunologia
Macrófagos/parasitologia
Macrófagos/patologia
Masculino
Camundongos
Camundongos Endogâmicos BALB C
Osteomielite/imunologia
Osteomielite/patologia
Author
Affilliation
Federal University of Maranhão. Nucleus of Tropical Pathology and Social Medicine. São Luís, MA, Brasil / University of São Paulo. Faculty of Medicine. Laboratory of Pathology of Infectious Diseases. Department of Pathology. São Paulo, SP, Brasil
State University of Maranhão. Faculty of Veterinary Medicine. Laboratory of Histology. São Luís, MA, Brasil
University of São Paulo. Faculty of Medicine. Laboratory of Pathology of Infectious Diseases. Department of Pathology. São Paulo, SP, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Federal University of Maranhão. Nucleus of Tropical Pathology and Social Medicine. São Luís, MA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
University of São Paulo. Faculty of Medicine. Laboratory of Pathology of Infectious Diseases. Department of Pathology. São Paulo, SP, Brasil
State University of Maranhão. Faculty of Veterinary Medicine. Laboratory of Histology. São Luís, MA, Brasil
University of São Paulo. Faculty of Medicine. Laboratory of Pathology of Infectious Diseases. Department of Pathology. São Paulo, SP, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Federal University of Maranhão. Nucleus of Tropical Pathology and Social Medicine. São Luís, MA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
University of São Paulo. Faculty of Medicine. Laboratory of Pathology of Infectious Diseases. Department of Pathology. São Paulo, SP, Brasil
Abstract
Experimental animal models have been used for the study of the physiopathogenesis of leishmaniasis, on some occasions with
success, while in other situations such as bone alterations that accompany tegumentary leishmaniasis, especially in diffuse cutaneous
form (DCL), the mechanisms are still unknown. In the present study, we determined these alterations in an animal model susceptible
to Leishmania (L) amazonensis. Amastigotes of L. (L) amazonensis isolated from patients with diffuse cutaneous leishmaniasis
(DCL) were inoculated into the hind paws of eight BALB/c mice, macroscopic and histopathological aspects were analyzed. After
90 and 120 days of evolution, histopathological analysis demonstrated a mononuclear cell infiltrate rich in plasma cells and intense
parasitism of intra- and extra-medullary macrophages, with areas of bone necrosis and discrete involvement of cartilaginous tissue.
The results show that the inflammatory process developed during L. (L) amazonensis infection might cause bone tissue destruction
and secondarily affect the joints
DeCS
Leishmania/crescimento & desenvolvimentoLeishmaniose Tegumentar Difusa/patologia
Osteomielite/parasitologia
Animais
Modelos Animais de Doenças
Membro Posterior/parasitologia
Membro Posterior/patologia
Histocitoquímica
Humanos
Leishmaniose Tegumentar Difusa/imunologia
Leishmaniose Tegumentar Difusa/parasitologia
Macrófagos/imunologia
Macrófagos/parasitologia
Macrófagos/patologia
Masculino
Camundongos
Camundongos Endogâmicos BALB C
Osteomielite/imunologia
Osteomielite/patologia
Share