Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/9340
Title: Evolutionary histories of expanded peptidase families in Schistosoma mansoni
Authors: Silva, Larissa Lopes
Marcet-Houben, Marina
Zerlotini, Adhemar
Gabaldón, Toni
Oliveira, Guilherme Corrêa
Nahum, Laila Alves
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Grupo de Genômica e Biologia Computacional. Belo Horizonte, MG, Brasil/Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Centro de Excelência em Bioinformática. Belo Horizonte, MG, Brasil/Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brasil
Universitat Pompeu Fabra. Centre de Regulació Genòmica. Bioinformatics and Genomics Programme. Barcelona, Spain
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Grupo de Genômica e Biologia Computacional. Belo Horizonte, MG, Brasil/Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Centro de Excelência em Bioinformática. Belo Horizonte, MG, Brasil
Universitat Pompeu Fabra. Centre de Regulació Genòmica. Bioinformatics and Genomics Programme. Barcelona, Spain
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Grupo de Genômica e Biologia Computacional. Belo Horizonte, MG, Brasil/Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Centro de Excelência em Bioinformática. Belo Horizonte, MG, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Grupo de Genômica e Biologia Computacional. Belo Horizonte, MG, Brasil/Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Centro de Excelência em Bioinformática. Belo Horizonte, MG, Brasil
Abstract: Schistosoma mansoni is one of the three main causative agents of human schistosomiasis, a major health problem with a vast socio-economic impact. Recent advances in the proteomic analysis of schistosomes have revealed that peptidases are the main virulence factors involved in the pathogenesis of this disease. In this context, evolutionary studies can be applied to identify peptidase families that have been expanded in genomes over time in response to different selection pressures. Using a phylogenomic approach, we searched for expanded endopeptidase families in the S. mansoni predicted proteome with the aim of contributing to the knowledge of such enzymes as potential therapeutic targets. We found three endopeptidase families that comprise leishmanolysins (metallopeptidase M8 family), cercarial elastases (serine peptidase S1 family) and cathepsin D proteins (aspartic peptidase A1 family). Our results suggest that the Schistosoma members of these families originated from successive gene duplication events in the parasite lineage after its diversification from other metazoans. Overall, critical residues are conserved among the duplicated genes/proteins. Furthermore, each protein family displays a distinct evolutionary history. Altogether, this work provides an evolutionary view of three S. mansoni peptidase families, which allows for a deeper understanding of the genomic complexity and lineage-specific adaptations potentially related to the parasitic lifestyle.
Keywords: phylogenomics
maximum likelihood analysis
homology prediction
functional annotation
proteases
paralogous families
parasite genomics
Issue Date: 2011
Publisher: Fundação Oswaldo Cruz
Citation: SILVA, Larissa Lopes et al. Evolutionary histories of expanded peptidase families in Schistosoma mansoni. Memórias do Instituto Oswaldo Cruz, v. 106, n. 7, p. 77-864, 2011
ISSN: 0074-0276
http://dx.doi.org/10.1590/S0074-02762011000700013
Copyright: open access
Appears in Collections:MG - IRR - Artigos de Periódicos

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