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Title: Apoptosis and apoptotic mimicry in Leishmania: an evolutionary perspective
Authors: El-Hani, Charbel Niño
Borges, Valeria de Matos
Wanderley, João Luiz Mendes
Barcinski, Marcello André
Affilliation: Universidade Federal da Bahia. Instituto de Biologia. Laboratório de Ensino, História e Filosofia de Biologia. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Investigação em Imunologia. Salvador, BA, Brasil.
Universidade Federal do Rio de Janeiro. Pólo Universitário Macaé. Macaé, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
Abstract: Apoptotic death and apoptotic mimicry are defined respectively as a non-accidental death and as the mimicking of an apoptotic-cell phenotype, usually by phosphatidylserine (PS) exposure. In the case of the murine infection by Leishmania spp, apoptotic death has been described in promastigotes and apoptotic mimicry in amastigotes. In both situations they are important events of the experimental murine infection by this parasite. In the present review we discuss what features we need to consider if we want to establish if a behavior shown by Leishmania is altruistic or not: does the behavior increases the fitness of organisms other than the one showing it? Does this behavior have a cost for the actor? If we manage to show that a given behavior is costly for the actor and beneficial for the recipient of the action, we will be able to establish it as altruistic. From this perspective, we can argue that apoptotic-like death and apoptotic mimicry are both altruistic with the latter representing a weaker altruistic behavior than the former.
Keywords: Leishmania spp
Apoptotic mimicry
unicellular parasites
DeCS: Apoptose
Evolução Biológica
Issue Date: 2012
Publisher: Frontiers
Citation: EL-HANI, C. N. et al. Apoptosis and apoptotic mimicry in Leishmania: an evolutionary perspective. Frontiers in Cellular and Infection Microbiology, v. 2, p. 1-6, 2012.
DOI: 10.3389/fcimb.2012.00096
ISSN: 2235-2988
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos
BA - IGM - Artigos de Periódicos

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