| Author | Porto, Maria Aurélia da Fonseca | |
| Author | Neva, Franklin A | |
| Author | Bittencourt, Helito Mascarenhas | |
| Author | Lisboa, Waldir | |
| Author | Thompson, Robert | |
| Author | Alcantara, Luiz Carlos Júnior | |
| Author | Carvalho Filho, Edgar Marcelino | |
| Access date | 2015-02-11T14:09:32Z | |
| Available date | 2015-02-11T14:09:32Z | |
| Document date | 2001 | |
| Citation | PORTO, A. F. et al. HTLV-1 decreases Th2 type of immune response in patients with strongyloidiasis. Parasite Immunology, v. 23, n. 9, p. 503-507, 2001 | pt_BR |
| ISSN | 0141-9838 | |
| URI | https://www.arca.fiocruz.br/handle/icict/9487 | |
| Language | eng | pt_BR |
| Publisher | Wiley | pt_BR |
| Rights | open access | pt_BR |
| Title | HTLV-1 decreases Th2 type of immune response in patients with strongyloidiasis. | pt_BR |
| Type | Article | pt_BR |
| Abstract | Eosinophils, immunoglobilin (Ig)E and cytokines have
important roles in defence mechanisms against helminths.
In this study, the influence of HTLV-1 infection, characterized
by a Th1 type of immune response, was evaluated on
the cytokine pattern and parasitic specific IgE response in
patients with strongyloidiasis. Patients were divided into
four groups: strongyloidiasis without HTLV-1 infection,
strongyloidiasis with HTLV-1, HTLV-1 without strongyloidiasis
and controls without either helminth infection or
HTLV-1. The cytokine profile was determined in supernatants
of mononuclear cells stimulated with Strongyloides
stercoralis crude antigen and the parasite specific IgE was
measured by ELISA. Patients coinfected with HTLV-1 had
higher levels of interfron (IFN)-g and interleukin (IL)-10
(P , 0´05) and lower levels of IL-5 and IgE (P , 0´05)
than patients with strongyloidiasis without HTLV-1. There
was an inverse relationship between IFN-g and IL-5
(P 0´01; rs 2 0´37) and between IFN-g and parasite
specific IgE (P 0´01; rs 2 0´39), and a direct
relationship between IFN-g and IL-10 (P 0´04;
rs 0´35). These data show that coinfection with HTLV-1
decreases IL-5 and IgE responses in patients with
strongyloidiasis consistent with a relative switch from Th2
to Th1 response. Immunological responses such as these are
important in the control of this helminthic infection. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
| Affilliation | National Institute of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Parasitic Diseases. Bethesda, MD, USA | pt_BR |
| Affilliation | Instituto de Gastroenterologia e Hepatologia. Salvador, BA, Brasil | pt_BR |
| Affilliation | Serviço de Transfusão de Sangue. Salvador, BA, Brasil | pt_BR |
| Affilliation | National Institute of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Parasitic Diseases. Bethesda, MD, USA | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil | pt_BR |
| Affilliation | Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
| Subject | HTLV-1 | pt_BR |
| Subject | Strongyloidiasis | pt_BR |
| Subject | IgE | pt_BR |
| Subject | S. stercoralis | pt_BR |
| DeCS | Citocinas/sangue | pt_BR |
| DeCS | Infecções por HTLV-I/imunologia | pt_BR |
| DeCS | Strongyloides stercoralis/imunologia | pt_BR |
| DeCS | Estrongiloidíase/imunologia | pt_BR |
| DeCS | Células Th2/imunologia | pt_BR |
| DeCS | Adulto | pt_BR |
| DeCS | Animais | pt_BR |
| DeCS | Anticorpos Anti-Helmínticos/sangue | pt_BR |
| DeCS | Células Cultivadas | pt_BR |
| DeCS | Citocinas/biossíntese | pt_BR |
| DeCS | Infecções por HTLV-I/sangue | pt_BR |
| DeCS | Vírus 1 Linfotrópico T Humano/imunologia | pt_BR |
| DeCS | Humanos | pt_BR |
| DeCS | Imunoglobulina E/sangue | pt_BR |
| DeCS | Interferon gama/sangue | pt_BR |
| DeCS | Interleucina-10/sangue | pt_BR |
| DeCS | Leucócitos Mononucleares/citologia | pt_BR |
| DeCS | Estrongiloidíase/complicações | pt_BR |
