Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/9487
Title: HTLV-1 decreases Th2 type of immune response in patients with strongyloidiasis.
Authors: Porto, Maria Aurélia da Fonseca
Neva, Franklin A
Bittencourt, Helito Mascarenhas
Lisboa, Waldir
Thompson, Robert
Alcantara, Luiz Carlos Júnior
Carvalho Filho, Edgar Marcelino
Affilliation: Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil
National Institute of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Parasitic Diseases. Bethesda, MD, USA
Instituto de Gastroenterologia e Hepatologia. Salvador, BA, Brasil
Serviço de Transfusão de Sangue. Salvador, BA, Brasil
National Institute of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Parasitic Diseases. Bethesda, MD, USA
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, Brasil
Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil
Abstract: Eosinophils, immunoglobilin (Ig)E and cytokines have important roles in defence mechanisms against helminths. In this study, the influence of HTLV-1 infection, characterized by a Th1 type of immune response, was evaluated on the cytokine pattern and parasitic specific IgE response in patients with strongyloidiasis. Patients were divided into four groups: strongyloidiasis without HTLV-1 infection, strongyloidiasis with HTLV-1, HTLV-1 without strongyloidiasis and controls without either helminth infection or HTLV-1. The cytokine profile was determined in supernatants of mononuclear cells stimulated with Strongyloides stercoralis crude antigen and the parasite specific IgE was measured by ELISA. Patients coinfected with HTLV-1 had higher levels of interfron (IFN)-g and interleukin (IL)-10 (P , 0´05) and lower levels of IL-5 and IgE (P , 0´05) than patients with strongyloidiasis without HTLV-1. There was an inverse relationship between IFN-g and IL-5 (P 0´01; rs 2 0´37) and between IFN-g and parasite specific IgE (P 0´01; rs 2 0´39), and a direct relationship between IFN-g and IL-10 (P 0´04; rs 0´35). These data show that coinfection with HTLV-1 decreases IL-5 and IgE responses in patients with strongyloidiasis consistent with a relative switch from Th2 to Th1 response. Immunological responses such as these are important in the control of this helminthic infection.
Keywords: HTLV-1
Strongyloidiasis
IgE
S. stercoralis
DeCS: Citocinas/sangue
Infecções por HTLV-I/imunologia
Strongyloides stercoralis/imunologia
Estrongiloidíase/imunologia
Células Th2/imunologia
Adulto
Animais
Anticorpos Anti-Helmínticos/sangue
Células Cultivadas
Citocinas/biossíntese
Infecções por HTLV-I/sangue
Vírus 1 Linfotrópico T Humano/imunologia
Humanos
Imunoglobulina E/sangue
Interferon gama/sangue
Interleucina-10/sangue
Leucócitos Mononucleares/citologia
Estrongiloidíase/complicações
Issue Date: 2001
Publisher: Wiley
Citation: PORTO, A. F. et al. HTLV-1 decreases Th2 type of immune response in patients with strongyloidiasis. Parasite Immunology, v. 23, n. 9, p. 503-507, 2001
ISSN: 0141-9838
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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