Author | Marques, Franciane Santos | |
Author | Silva, Joselli Santos | |
Author | Couto, Ricardo David | |
Author | Barreto Junior, Elton Pereira de Sá | |
Author | Santos, Ricardo Ribeiro dos | |
Author | dosSantos, Washington Luis Conrado | |
Author | Soares, Milena Botelho Pereira | |
Access date | 2015-04-06T16:29:32Z | |
Available date | 2015-04-06T16:29:32Z | |
Document date | 2013 | |
Citation | MARQUES, F. S. et al. Transplantation of bone marrow mononuclear cells reduces mortality and improves renal function on mercury-induced kidney injury in mice. Renal Failure, v. 35, n. 5, p. 776–781, 2013. | pt_BR |
ISSN | 1525-6049 | |
ISSN | 10.3109/0886022X.2013.780660 | |
URI | https://www.arca.fiocruz.br/handle/icict/9880 | |
Language | eng | pt_BR |
Publisher | Informa Healthcare | pt_BR |
Rights | open access | pt_BR |
Title | Transplantation of bone marrow mononuclear cells reduces mortality and improves renal function on mercury-induced kidney injury in | pt_BR |
Type | Article | pt_BR |
Abstract | OBJECTIVE: Recent studies have demonstrated the therapeutic effects of bone marrow-derived cells in tissue regeneration. The aim of this study was to investigate the effects of bone marrow mononuclear cell (BMMC) transplantation in a mouse model of acute renal failure (ARF) induced by mercuric chloride. METHODS: BMMC was isolated from male BALB/c mice and injected into female mice treated with a lethal dose (LD90) of mercuric chloride. Survival rate, histopathological analysis, and assessment of urea, creatinine, sodium, potassium, and mercury levels were carried out. RESULTS: Cellular therapy with BMMC significantly reduced the mortality induced by mercuric chloride (p < 0.05). This finding correlated with a decrease in serum levels of urea (p = 0.04) and potassium (p < 0.01). However, no differences in renal morphology were observed when BMMC-treated and control group were compared. CONCLUSION: Transplanted BMMC improve renal function and reduce mortality and, therefore, may represent a new therapeutic alternative to treat ARF. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Laboratório de Bioquímica Clínica. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil | pt_BR |
Subject | Mercuric chloride | pt_BR |
Subject | Acute renal failure | pt_BR |
Subject | Bone marrow mononuclear cells | pt_BR |
Subject | Cell therapy | pt_BR |
DeCS | Lesão Renal Aguda/terapia | pt_BR |
DeCS | Transplante de Medula Óssea | pt_BR |
DeCS | Monócitos/transplante | pt_BR |
DeCS | Lesão Renal Aguda/induzido quimicamente | pt_BR |
DeCS | Animais | pt_BR |
DeCS | Modelos Animais de Doenças | pt_BR |
DeCS | Feminino | pt_BR |
DeCS | Masculino | pt_BR |
DeCS | Cloreto de Mercúrio | pt_BR |
DeCS | Camundongos | pt_BR |
DeCS | Camundongos Endogâmicos BALB C | pt_BR |