Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/9880
Title: Transplantation of bone marrow mononuclear cells reduces mortality and improves renal function on mercury-induced kidney injury in
Authors: Marques, Franciane Santos
Silva, Joselli Santos
Couto, Ricardo David
Barreto Junior, Elton Pereira de Sá
Santos, Ricardo Ribeiro dos
dosSantos, Washington Luis Conrado
Soares, Milena Botelho Pereira
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia. Laboratório de Bioquímica Clínica. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil
Abstract: OBJECTIVE: Recent studies have demonstrated the therapeutic effects of bone marrow-derived cells in tissue regeneration. The aim of this study was to investigate the effects of bone marrow mononuclear cell (BMMC) transplantation in a mouse model of acute renal failure (ARF) induced by mercuric chloride. METHODS: BMMC was isolated from male BALB/c mice and injected into female mice treated with a lethal dose (LD90) of mercuric chloride. Survival rate, histopathological analysis, and assessment of urea, creatinine, sodium, potassium, and mercury levels were carried out. RESULTS: Cellular therapy with BMMC significantly reduced the mortality induced by mercuric chloride (p < 0.05). This finding correlated with a decrease in serum levels of urea (p = 0.04) and potassium (p < 0.01). However, no differences in renal morphology were observed when BMMC-treated and control group were compared. CONCLUSION: Transplanted BMMC improve renal function and reduce mortality and, therefore, may represent a new therapeutic alternative to treat ARF.
Keywords: Mercuric chloride
Acute renal failure
Bone marrow mononuclear cells
Cell therapy
DeCS: Lesão Renal Aguda/terapia
Transplante de Medula Óssea
Monócitos/transplante
Lesão Renal Aguda/induzido quimicamente
Animais
Modelos Animais de Doenças
Feminino
Masculino
Cloreto de Mercúrio
Camundongos
Camundongos Endogâmicos BALB C
Issue Date: 2013
Publisher: Informa Healthcare
Citation: MARQUES, F. S. et al. Transplantation of bone marrow mononuclear cells reduces mortality and improves renal function on mercury-induced kidney injury in mice. Renal Failure, v. 35, n. 5, p. 776–781, 2013.
ISSN: 1525-6049
10.3109/0886022X.2013.780660
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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