Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/9923
Title: Immune reconstitution inflammatory syndrome in HIV and sporotrichosis coinfection: report of two cases and review of the literature
Authors: Lyra, Marcelo Rosandiski
Nascimento, Maria Letícia Fernandes Oliveira
Varon, Andréa Gina
Pimentel, Maria Inês Fernandes
Antonio, Liliane de Fátima
Saheki, Maurício Naoto
Pacheco, Sandro Javier Bedoya
Valle, Antonio Carlos Francesconi do
Affilliation: Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil
Hospital Central do Exército. Departamento de Doenças Infecciosas. Rio de Janeiro, RJ, Brasil
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Micobactéria. Rio de Janeiro, RJ, Brasil
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Vigilância em Leishmanioses. Rio de Janeiro, RJ, Brasil
Abstract: We report 2 cases of patients with immune reconstitution infl ammatory syndrome (IRIS) associated with cutaneous disseminated sporotrichosis and human immunodefi ciency virus (HIV) coinfection. The patients received specifi c treatment for sporotrichosis. However, after 4 and 5 weeks from the beginning of antiretroviral therapy, both patients experienced clinical exacerbation of skin lesions despite increased T CD4+ cells (T cells cluster of differentiation 4 positive) count and decreased viral load. Despite this exacerbation, subsequent mycological examination after systemic corticosteroid administration did not reveal fungal growth. Accordingly, they were diagnosed with IRIS. However, the sudden withdrawal of the corticosteroids resulted in the recurrence of IRIS symptoms. No serious adverse effects could be attributed to prednisone. We recommend corticosteroid treatment for mildto- moderate cases of IRIS in sporotrichosis and HIV coinfection with close follow-up.
DeCS: HIV
Sporotrichosis
Immune Reconstitution Inflammatory Syndrome
Iris
Issue Date: 2014
Publisher: Sociedade Brasileira de Medicina Tropical
Citation: LYRA, Marcelo Rosandiski et al. Immune reconstitution inflammatory syndrome in HIV and sporotrichosis coinfection: report of two cases and review of the literature. Rev. Soc. Bras. Med. Trop., Uberaba, v.47, n.6, p.806-809, 2014.
DOI: 10.1590/0037-8682-0146-2014
ISSN: 0037-8682
Copyright: open access
Appears in Collections:INI - Artigos de Periódicos




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