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IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME IN HIV AND SPOROTRICHOSIS COINFECTION: REPORT OF TWO CASES AND REVIEW OF THE LITERATURE
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Abstract
We report 2 cases of patients with immune reconstitution infl ammatory syndrome (IRIS) associated with cutaneous disseminated
sporotrichosis and human immunodefi ciency virus (HIV) coinfection. The patients received specifi c treatment for sporotrichosis.
However, after 4 and 5 weeks from the beginning of antiretroviral therapy, both patients experienced clinical exacerbation of
skin lesions despite increased T CD4+ cells (T cells cluster of differentiation 4 positive) count and decreased viral load. Despite
this exacerbation, subsequent mycological examination after systemic corticosteroid administration did not reveal fungal growth.
Accordingly, they were diagnosed with IRIS. However, the sudden withdrawal of the corticosteroids resulted in the recurrence of
IRIS symptoms. No serious adverse effects could be attributed to prednisone. We recommend corticosteroid treatment for mildto-
moderate cases of IRIS in sporotrichosis and HIV coinfection with close follow-up.
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