Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/9959
Title: Decreased humoral and pathologic responses in undernourished mice infected with Schistosoma mansoni.
Authors: Oliveira, Sheilla Andrade de
Silva, Luciana Menezes da
Barbosa Junior, Aryon de Almeida
Santos, Ricardo Ribeiro dos
Coutinho, Elsimar Metzker
Andrade, Zilton de Araújo
Soares, Milena Botelho Pereira
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recife, PE, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recife, PE, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract: : We previously demonstrated that mice subjected to a hypoproteinic diet showed milder chronic lesions on infection with Schistosoma mansoni than normally fed mice. Here we compare the immune response of well-nourished and undernourished mice with chronic S. mansoni infection. The proliferative response and cytokine (IFN-gamma and IL-5) production of splenocytes from undernourished mice against the soluble egg antigen (SEA) of S. mansoni or concanavalin A was similar to that of well-nourished mice. The levels of SEA-specific IgG1, IgG2b and IgG3 antibodies were significantly higher in the sera of well-nourished mice in comparison with undernourished mice. Undernourished animals also exhibited diminished periovular granuloma size compared to well-nourished infected controls. Our results support the importance of host nutritional status in the humoral immune response of mice and its effects on the development of periovular granulomas in malnourished animals infected with S. mansoni.
DeCS: Anticorpos Anti-Helmínticos/sangue
Granuloma/patologia
Transtornos Nutricionais/imunologia
Schistosoma mansoni/imunologia
Esquistossomose mansoni/patologia
Fenômenos Fisiológicos da Nutrição Animal
Animais
Antígenos de Helmintos/imunologia
Feminino
Granuloma/imunologia
Fígado/imunologia
Ativação Linfocitária
Masculino
Camundongos
Transtornos Nutricionais/patologia
Esquistossomose mansoni/imunologia
Baço/patologia
Issue Date: 2004
Publisher: Springer Verlag
Citation: OLIVEIRA, S. A. Decreased humoral and pathologic responses in undernourished mice infected with Schistosoma mansoni. Parasitology Research, v. 93, n. 1, p. 30-35, 2004.
DOI: 10.1007/s00436-004-1088-6
ISSN: 0932-0113
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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