Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/10057
Title: In vitro and in vivo activity of the chloroaryl-substituted imidazole viniconazole against Trypanosoma cruzi
Authors: Silva, Cristiane França da
Batista, Denise da Gama Jaen
Batista, Marcos Meuser
Lionel, Jessica
Hammer, Erica Ripoll
Brun, Reto
Soeiro, Maria de Nazaré Correia
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil
Swiss Tropical and Public Health Institute.Department of Medical Parasitology and Infection Biology. Basel, Switzerland.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil
Abstract: Chagas disease (CD) is caused by the intracellular protozoan parasite Trypanosoma cruzi and affects more than 10 million people in poor areas of Latin America. There is an urgent need for alternative drugs with better safety, broader efficacy, lower costs and shorter time of administration. Thus the biological activity of viniconazole, a chloroaryl-substituted imidazole was investigated using in vitro and in vivo screening models of T. cruzi infection. Ultrastructural findings demonstrated that the most frequent cellular damage was associated with plasma membrane (blebs and shedding events), Golgi (swelling aspects) and the appearance of large numbers of vacuoles suggesting an autophagic process. Our data demonstrated that although this compound is effective against bloodstream and intracellular forms (16 and 24 μM, respectively) in vitro, it does not present in vivo efficacy. Due to the urgent need for novel agents against T. cruzi, the screening of natural and synthetic products must be further supported with the aim of finding more selective and affordable drugs for CD.
Keywords: Chagas Disease
Tripanosoma Cruzi
Chloroaryl-substituted imidazole
Viniconazole
Chemotherapy
In vitro
keywords: Doença de Chagas
Tripanosoma Cruzi
Quimioterapia
Infecções por Protozoários
Issue Date: 2014
Publisher: Cambridge University Press
Citation: SILVA, Cristiane França da et al. In vitro and in vivo activity of the chloroaryl-substituted imidazole viniconazole against Trypanosoma cruzi. Parasitology, n.141, p. 367-373, 2014.
DOI: 10.1017/S0031182013001601
ISSN: 0031-1820
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

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