Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/10612
Title: Anti-adrenergic and muscarinic receptor autoantibodies in a canine model of Chagas disease and their modulation by benznidazole
Authors: Daliry, Anissa
Caldas, Ivo Santana
Diniz, Livia de Figueiredo
Torres, Rosália Morais
Talvani, André
Bahia, Maria Therezinha
Carvalho, Antônio Carlos Campos de
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.
Universidade Federal de Ouro Preto. Ouro Preto, MG, Brasil.
Universidade Federal de Ouro Preto. Ouro Preto, MG, Brasil.
Universidade Federal de Ouro Preto. Ouro Preto, MG, Brasil.
Universidade Federal de Ouro Preto. Ouro Preto, MG, Brasil.
Universidade Federal de Ouro Preto. Ouro Preto, MG, Brasil.
Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.
Abstract: Chronic chagasic cardiomyopathy (CCC) is a public health problem still without a defined physiopathology. It results from a chronic infection by Trypanosoma cruzi and is characterized by irreversible lesions to the heart. The contribution of autoimmune processes to cardiac dysfunctions observed in CCC has been hypothesized by several authors [1–3]. Those studies demonstrated the presence of IgG components in sera of patients with CCC and dilated cardiomyopathy interacting with cardiac β1-adrenergic (anti-β1-AR) and muscarinic membrane receptors (anti-M2-CR) [3].
Keywords: Typanosoma cruzi
Cadiomiopathy
Autoantibodies
Beta-adrenergic receptor
Muscarinic cholinergic receptor
DeCS: Cardiomiopatia Chagásica
Autoanticorpos
Trypanosoma cruzi
Issue Date: 2014
Publisher: Elsevier
Citation: DALIRY, Anissa et al. Anti-adrenergic and muscarinic receptor autoantibodies in a canine model of Chagas disease and their modulation by benznidazole. International Journal of Cardiology, v.170, n.3, p.e66–e67, 2014.
DOI: 10.1016/j.ijcard.2013.11.022
ISSN: 0167-5273
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

Files in This Item:
File Description SizeFormat 
anissa_daliryetal_IOC_2014.pdf123.71 kBAdobe PDFView/Open


FacebookTwitterDeliciousLinkedInGoogle BookmarksBibTex Format mendeley Endnote DiggMySpace

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.