| Author | Araujo, Natalia M. | |
| Author | Araujo, Oscar C. | |
| Author | Silva, Edinete M. | |
| Author | Nogueira, Cristiane A. Villela | |
| Author | Nabuco, Letícia C. | |
| Author | Parana, Raymundo | |
| Author | Bessone, Fernando | |
| Author | Gomes, Selma A. | |
| Author | Tiepo, Christian | |
| Author | Kay, Alan | |
| Access date | 2015-09-21T17:25:15Z | |
| Available date | 2015-09-21T17:25:15Z | |
| Document date | 2013 | |
| Citation | ARAUJO, Natalia M.; et al. Identification of novel recombinants of hepatitis B virus genotypes F and G in human immunodeficiency virus-positive patients from Argentina and Brazil. Journal of General Virology, v. 94, p.150–158, 2013. | pt_BR |
| ISSN | 0022-1317 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/11685 | |
| Language | eng | pt_BR |
| Publisher | Society for General Microbiology | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Brasil | pt_BR |
| Subject in Portuguese | Soropositividade | pt_BR |
| Title | Identification of novel recombinants of hepatitis B virus genotypes F and G in human immunodeficiency virus-positive patients from Argentina and Brazil | pt_BR |
| Type | Article | |
| DOI | 10.1099/vir.0.047324-0 | pt_BR |
| Abstract | Hepatitis B virus (HBV) genotype G (HBV/G) infection is almost always detected along with a coinfecting
HBV strain that can supply HBeAg, typically HBV/A2. In this study we describe, in two
human immunodeficiency virus (HIV)-positive patients from Argentina and Brazil, the first report of
HBV/G infection in Argentina and co-circulation of HBV/G, HBV/F and G/F recombinants in the
American continent. HBV isolates carrying the 36 bp insertion of HBV/G were the most prevalent
in both patients, with .99% of colonies hybridizing to a probe specific for this insertion.
Phylogenetic analyses of full-length genomes and precore/core fragments revealed that F4 and
F1b were the co-infecting subgenotypes in the Brazilian and Argentinian patients, respectively.
Bootscanning analysis provided evidence of recombination in several clones from both patients,
with recombination breakpoints located mainly at the precore/core region. These data should
encourage further investigations on the clinical implications of HBV/G recombinants in HBV/HIV
co-infected patients. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Centre de Recherche en Cancérologie de Lyon – INSERM U 1052/CNRS UMR 5286. Lyon, France. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Divisão de Hepatologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Divisão de Hepatologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal da Bahia. Hospital Universitário Prof. Edgard Santos. Departamento de Hepato-Gastroenterologia. Salvador, BA, Brasil. | pt_BR |
| Affilliation | University of Rosario. School of Medicine. Department of Gastroenterology and Hepatology. Rosario, Argentina. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Centre de Recherche en Cancérologie de Lyon – INSERM U 1052/CNRS UMR 5286. Lyon, France. | pt_BR |
| Affilliation | Centre de Recherche en Cancérologie de Lyon – INSERM U 1052/CNRS UMR 5286. Lyon, France. | pt_BR |
| Subject | Hepatitis B | pt_BR |
| Subject | Genotypes F and G | pt_BR |
| Subject | Human Immunodeficiency | pt_BR |
| Subject | Argentina | pt_BR |
| Subject | Brazil | pt_BR |
| Subject | Virus-positive patients | pt_BR |
| DeCS | Vírus da Hepatite B | pt_BR |
| DeCS | Imunodeficiência Humana | pt_BR |
