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IDENTIFICATION OF NOVEL RECOMBINANTS OF HEPATITIS B VIRUS GENOTYPES F AND G IN HUMAN IMMUNODEFICIENCY VIRUS-POSITIVE PATIENTS FROM ARGENTINA AND BRAZIL
Genotypes F and G
Human Immunodeficiency
Argentina
Brazil
Virus-positive patients
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Abstract
Hepatitis B virus (HBV) genotype G (HBV/G) infection is almost always detected along with a coinfecting
HBV strain that can supply HBeAg, typically HBV/A2. In this study we describe, in two
human immunodeficiency virus (HIV)-positive patients from Argentina and Brazil, the first report of
HBV/G infection in Argentina and co-circulation of HBV/G, HBV/F and G/F recombinants in the
American continent. HBV isolates carrying the 36 bp insertion of HBV/G were the most prevalent
in both patients, with .99% of colonies hybridizing to a probe specific for this insertion.
Phylogenetic analyses of full-length genomes and precore/core fragments revealed that F4 and
F1b were the co-infecting subgenotypes in the Brazilian and Argentinian patients, respectively.
Bootscanning analysis provided evidence of recombination in several clones from both patients,
with recombination breakpoints located mainly at the precore/core region. These data should
encourage further investigations on the clinical implications of HBV/G recombinants in HBV/HIV
co-infected patients.
Keywords
Hepatitis BGenotypes F and G
Human Immunodeficiency
Argentina
Brazil
Virus-positive patients
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