| Author | Morais, Christina Maria Queiroz de Jesus | |
| Author | Assis, Edson Fernandes | |
| Author | Cordeiro, Renato S. B. | |
| Author | Barbosa Filho, José Maria | |
| Author | Lima, Wothan T. | |
| Author | Silva, Zilma L. | |
| Author | Bozza, Patrícia T. | |
| Author | Faria Neto, Hugo Caire de Castro | |
| Access date | 2015-11-10T17:37:29Z | |
| Available date | 2015-11-10T17:37:29Z | |
| Document date | 2000 | |
| Citation | MORAIS, C. M. Q. J. et al. Yangambin, a lignan obtained from Ocotea duckei, differentiates putative PAF receptor subtypes in the gastrointestinal tract of rats. Planta Med., Stuttgart, v. 66, n. 3, p. 211-216, 2000. | pt_BR |
| ISSN | 0032-0943 | |
| URI | https://www.arca.fiocruz.br/handle/icict/12151 | |
| Language | eng | pt_BR |
| Publisher | Thieme | pt_BR |
| Rights | open access | pt_BR |
| Subject in Portuguese | Iangambina | pt_BR |
| Subject in Portuguese | Ocotea duckei | pt_BR |
| Subject in Portuguese | Lauráceas | pt_BR |
| Subject in Portuguese | Fator de Ativação Plaquetária | pt_BR |
| Subject in Portuguese | Subtipos de Receptores D de Fator de Ativação Plaquetária | pt_BR |
| Subject in Portuguese | Produtos Naturais | pt_BR |
| Subject in Portuguese | Louro-de-cheiro | pt_BR |
| Title | Yangambin, a lignan obtained from Ocotea duckei, differentiates putative PAF receptor subtypes in the gastrointestinal tract of rats | en |
| Type | Article | pt_BR |
| DOI | http://dx.doi.org/10.1055/s-2000-8556 | |
| Abstract | We investigated the presence of PAF receptor subtypes in the tissues of the gastrointestinal tract, airways, blood vessels and in murine macrophages. For this purpose we have used a competitive PAF receptor antagonist, yangambin (YAN), extracted from the Brazilian plant “louro de cheiro” (Ocotea duckei Vattimo). Rat duodenum, jejunum, ileum, colon, stomach fundus, trachea and bronchia were removed and 1.5 - 2 cm muscle segments from those regions were mounted in a 10 ml organ bath with aerated physiological solution at 37 °C. PAF evoked a contraction of the rat jejunum, ileum, colon and stomach fundus. The contraction was slow and resistant to wash and was followed by desensitization to further doses of PAF. Contractions induced by PAF (10-6 M) were inhibited by YAN (10-7 to M - 2 × 10-5 M) and WEB 2086 (10-6 m to M-5 M) in rat jejunum, ileum and colon but not in the stomach fundus. In the rat stomach fundus only WEB 2086 (5 × 10-6 M) was able to block PAF-induced contraction. The contractions induced by acetylcholine, histamine, 5-hydroxytryptamine and vasopressin were not inhibited by prior administration of YAN. Yangambin also significantly inhibited PAF-induced vascular permeability in rat duodenum, jejunum, ileum, colon, and mesentery. Yangambin significantly inhibited PAF-induced lipid body formation in mice peritoneal macrophages. We suggest that YAN is a selective PAF antagonist which is able to discriminate putative PAF receptors subtypes present in the stomach fundus. | en |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde. Departamento de Química. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal da Paraíba. Laboratório de Tecnologia Farmacêutica. João Pessoa, PB, Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Instituto de Ciências Biomédicas. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Universidade de São Paulo. Instituto de Ciências Biomédicas. São Paulo, SP, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Yangambin | en |
| Subject | Ocotea duckei | en |
| Subject | Lauraceae | en |
| Subject | Platelet-activating Factor | en |
| Subject | PAF-receptor Subtypes | en |
| Subject | Natural Product | en |
| DeCS | Ocotoea | pt_BR |
| DeCS | Laurus | pt_BR |
| DeCS | Lignanas | pt_BR |
| DeCS | Lauraceae | pt_BR |
| DeCS | Ativação Plaquetária | pt_BR |
| DeCS | Produtos Biológicos | pt_BR |
